摘要
目的:分析CYP19A1 rs2899470多态性与子宫内膜异位症(EMs)合并不孕关系及辅助生殖(IVF-ET)妊娠结局。方法:选取2017年1月-2020年1月本院收治的104例EMs患者,其中51例为合并不孕症行IVF-ET患者为观察组,余53例为对照组。观察两组患者一般临床资料,分析基因多态性与不孕症患者IVF-ET中的获卵数、受精率、卵裂数及妊娠结局。结果:观察组携带TT基因或TG+TT基因比例高于对照组,携带TT及TG+TT基因与IVF-ET合并不孕症具有相关性(P<0.05);观察组中携带GG基因患者与携带TG+TT基因患者IVF-ET获卵数、卵裂率无差异(P>0.05),但携带GG基因患者MⅡ卵数、受精率、优质胚胎率高于携带TG+TT基因患者(P<0.05),异位妊娠率无差异(P>0.05),携带GG基因患者种植率、妊娠率高于携带TG+TT基因患者,流产率低于携带TG+TT基因患者(P<0.05)。结论:携带TG、TT基因的EMs患者合并不孕症风险可能增加,且携带TG、TT基因降低了患者IVF-ET妊娠几率,不利于术后妊娠结局。
Objective:To analyze the relationship between CYP19A1 RS2899470 polymorphism of infertility patients with endometriosis and their assisted reproduction outcomes(EMs).Methods:A total of 104 patients with EMs were selected and were divided 51 patients complicated with infertility who undergone IVF-ET in observation group and 53 were patients without infertility in control group from January 2017 to January 2020.The general clinical data of the patients in the two groups were observed.The number of eggs harvested,the fertilization rate,the cleavage number,and the pregnancy outcomes of infertility patients with CYP19A1 RS2899470 polymorphism after IVF-ET were analyzed.Results:The proportion of the patients carrying TT gene or TG+TT gene in the observation group was significantly higher than that of the patients in the control group,and carrying TT gene and TG and TT gene of the patients were correlated with their infertility(P<0.05).In the observation group,there were no significant differences in number of eggs harvested and the cleavage rate between the patients carrying GG gene and the patients carrying TG+TT gene(P>0.05).In the observation group,the number of MⅡeggs,the fertilization rate,and the high-quality embryo rate of the patients carrying GG gene were significantly higher than those of the patients carrying TG and TT gene(P<0.05),but there was no significant difference in the ectopic pregnancy rate between the patients carrying GG gene and the patients carrying TG and TT gene(P>0.05).In the observation group,the planting rate and the pregnancy rate of the patients carrying GG gene were significantly higher than those of the patients carrying TG+TT gene,and the abortion rate of the patients carrying GG gene was significantly lower(P>0.05).Conclusion:The patients with EMs and carrying TG and TT genes may have an increased risk of infertility,and carrying TG and TT genes can reduce the incidence of pregnancy of these patients after IVF-ET,which is not conducive to the pregnancy outcomes after IVF-ET.
作者
袁丽
陈宇
YUAN Li;CHEN Yu(The First Clinical College of Hubei University of Medicine,Shiyan,Hubei Province,442000;Shiyan Taihe Hospital/the Affiliated Hospital of Hubei University of Medicine)
出处
《中国计划生育学杂志》
2022年第1期122-125,共4页
Chinese Journal of Family Planning
关键词
子宫内膜异位症合并不孕症
基因多态性
辅助生殖
妊娠结局
Endometriosis complicated with infertility
Gene polymorphism
Assisted reproduction
Pregnancy outcomes
