摘要
背景:骨缺损再生修复是临床常见难题,骨组织的再生修复需要特定的微环境和生长因子参与。尼尔样1型生长因子(Nel-like molecular 1,Nell-1)是一种分泌性蛋白,同时也是是一种有效且无明显毒副作用的骨生长因子,目前大量研究表明Nell-1能够用于促进骨再生修复,有望成为骨再生修复的新方法。目的:对Nell-1调控成骨机制及其在骨再生修复方面的应用和前景进行综述。方法:以"nell-1,nel-like molecule 1,nel-like protein 1,neural EGF like protein 1,bone repairing,osteogenesis,osteogenic,regenerative medicine"或"Nell-1,nell-1蛋白,nel样1型分子,神经源性表皮生长因子样分子1,骨生成,成骨作用,骨修复,再生医学"等作为检索词,利用PubMed、中国知网、万方数据库、embase进行检索,选择从1996年12月15日至2017年11月1日有关Nell-1生长因子与成骨及骨再生修复应用方面的文献资料,排除重复性研究。结果与结论:Nell-1的发现最早与颅缝早闭相关,后来被证实为一种有效的骨生长因子,其具有抗脂肪分化、抑制炎症反应和无明显毒副作用等优点。目前大量动物实验已证明Nell-1可应用于促进骨再生修复,除此之外,Nell-1同时还有作为治疗骨质疏松症有效药物的巨大潜力,有望在未来成为用于骨再生修复的新方法。
BACKGROUND: Bone regeneration and repair for bone defects is a common problem in the clinic. Bone regeneration requires specific microenvironment and growth factors. Nel-like molecular 1 (Nell-1) is a secreted protein, and it is also an effective bone growth factor without toxic effect. Nell-1 has been shown to promote bone regeneration and repair, and it is expected to be a new method for bone regeneration and repair. OBJECTIVE: To review the mechanism of Nell-1 in osteogenesis and its application and prospects in bone regeneration and repair. METHODS: PubMed, CNKI, WanFang and Embase databases were searched for the literature addressing Nell-1 in osteogenesis, bone regeneration and repair published between December 15, 1996 and November 1, 2017. The keywords were “nell-1, nel-like molecule 1, nel-like protein 1, neural EGF like protein 1, bone repairing, osteogenesis, osteogenic, regenerative medicine” in English and Chinese, respectively. The repetitive studies were excluded. RESULTS AND CONCLUSION: Nell-1 was firstly found to be associated with craniosynostosis and later has been proved to be an effective bone growth factor. Nell-1 possesses the roles of anti-adipose differentiation, inhibiting inflammatory reaction without obvious toxic effects. A large number of animal experiments have proven that Nell-1 can be used to promote bone regeneration and repair. Additionally, it is also expected to be a potential drug for osteoporosis, and is a promising method in bone regeneration and repair.
作者
曹曦
崔伟
陈跃平
冯洋
路通
Cao Xi;Cui Wei;Chen Yueping;Feng Yang;Lu Tong(Department of Orthopedics, Changshu Hospital of Traditional Chinese Medicine, Changshu 215500, Jiangsu Province, China;Department of Orthopedic Traumaand Hand Surgery, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530001,Guangxi Zhuang Autonomous Region, China)
出处
《中国组织工程研究》
CAS
北大核心
2019年第8期1235-1240,共6页
Chinese Journal of Tissue Engineering Research
基金
广西自然科学基金课题(2015GXNSFAA139136)
中央支持地方高校发展专项资金:2017年骨外科学(04B2017082)~~
