摘要
骨与其他组织的再生往往需要种子细胞、支架材料和相关生长因子三方面的参与,而生长因子作为维持微环境的重要组成部分,对于组织再生起着重要作用。人类尼尔样-1型分子（Nel-like molecule-1,NELL-1）基因位于第11号染色体p15.1-p15.2,
Regeneration of bone tissue,as well as other tissues,requires involvement and interaction of cells,scaffolds and relevant growth factors,among which growth factors play a crucial role in maintaining the stability of microenvironment. Nel-like-type 1 molecule（ NELL-1）,a novel growth factor in tissue engineering,has been studied intensively in recent years. Researches mainly covered gene and protein structure and their expression profiling,biological function,molecular mechanisms and disease relevance. NELL-1 expressed in embryonic tissue is essential for growth and development of bone tissue.NELL-1 presents excellent abilities of inducing bone and cartilage regeneration,especially with high specificity to chondrocyte lineage. Compared with classic osteogenic growth factor bone morphogenetic protein 2（ BMP-2）,the process of osteogenesis interacted with NELL-1 exhibits stronger specificity,higher bone density and fewerside effects. Furthermore,a recent study shows synergistic effects of NELL-1 and BMP-2. NELL-1 enhances the osteogenic reaction induced by BMP-2 of cells and notably declines inflammation response caused by BMP-2. This review evaluates the current research progress of the function and application of NELL-1 by the systematic method of evidence-based medicine.
出处
《北京大学学报（医学版）》
CAS
CSCD
北大核心
2016年第2期380-383,共4页
Journal of Peking University:Health Sciences
