摘要
目的探讨高密度脂蛋白胆固醇(HDL-C)与老年冠心病患者临床预后的关联性。方法选自北华大学附属医院2015年9月至2017年9月收治的老年冠心病患者194例;根据不同病情程度分为稳定性心绞痛(SAP)53例、不稳定性心绞痛(UAP)77例、急性心肌梗死(AMI)64例。另选自北华大学附属医院于2015年9月至2017年9月健康体检者100例作为对照组。所有研究对象均于清晨空腹采集外周静脉血,分离血清标本,采用免疫透射浊度法测定HDL-C水平。比较冠心病各组和对照组、存活组和死亡组血清HDL-C水平。结果冠心病各组血清HDL-C水平低于对照组,差异有统计学意义(P<0.05);AMI组血清HDL-C水平低于UAP组和SAP组,差异有统计学意义(P<0.05);UAP组血清HDL-C水平低于SAP组,差异有统计学意义(P<0.05)。死亡组血清HDL-C水平低于存活组,差异有统计学意义(P<0.05)。结论老年冠心病患者血清HDL-C水平降低,且水平越低预后越差。
Objective To investigate the correlation between high density lipoprotein cholesterol(HDL-C)and the clinical prognosis in elderly patients with coronary heart disease(CHD).Methods One hundred and ninety-four elderly patients with CHD in the Affiliated Hospital of Beihua University from September 2015 to September 2017 were selected and divided into stable angina(SAP,53 cases),unstable angina pectoris(UAP,77 cases)and acute myocardial infarction(AMI,64 cases)according to different disease conditions.Other 100 individuals undergoing healthy physical examaination from September 2015 to September 2017 were selected as the control group.The fasting peripheral venous blood were collected from all the subjects in the early morning,and the serum samples were isolated and the content of HDL-C was measured by the immunoturbidimetric assay.The levels of serum HDL-C were compared among different CHD groups,the control group,the survival group and the death group.Results The serum HDL-C level of the CHD group were lower than that in the control group with statistical difference(P<0.05);the serum HDL-C level in the AMI group was lower than that in the UAP group and SAP group,and the difference was statistical difference(P<0.05);the serum HDL-C level in the UAP group was lower than that in the SAP group(P<0.05).The level of serum HDL-C in the death group was lower than that in the survival group(P<0.05).Conclusion The serum HDL-C level in elderly patients with CHD is decreased,moreover the lower the level is,the worse the prognosis is.
作者
朱艳彬
朱伟群
ZHU Yanbin;ZHU Weiqun(Third Department of Cardiology,Affiliated Hospital of Beihua University,Jilin,Jilin 132001,China;First Department of Internal Medicine,Jinyun County People′s Hospital,Jinyun,Zhejiang 321400,China)
出处
《重庆医学》
CAS
2018年第33期4260-4262,共3页
Chongqing medicine
关键词
高密度脂蛋白胆固醇
老年
冠心病
临床预后
关联性
high density lipoprotein cholesterol
elderly
coronary heart disease
clinical prognosis
correlation
