摘要
目的：探讨低水平高密度脂蛋白胆固醇（HDL-C）对冠心病患者经皮冠状动脉介入术（PCI）后肾脏功能的影响。方法：收集2012年2月至2014年6月来我院救治并行PCI术的冠心病患者300例,依据患者血液中HDLC水平的高低分为正常水平HDL-C组（179例,HDL-C≥1.04mmol/L）与低水平HDL-C组（121例,HDL-C〈1.04mmol/L）。比较分析两组患者的基本资料,并应用多因素Logistic回归分析对PCI术后发生肾损伤的危险因素。结果：与正常水平HDL-C组比较,低水平HDL-C组超重（30.73%比39.67%）、吸烟史（29.05%比41.32%）、心肌梗死史（35.20%比46.28%）、左室射血分数（LVEF）〈50%（18.99%比24.79%）、贫血（16.20%比27.27%）及肾损伤（12.85%比22.31%）比例显著升高,P〈0.05或〈0.01。多因素Logistic回归分析显示年龄、心梗史、贫血、LVEF〈50%、糖尿病、对比剂用量及低水平HDL-C是冠心病患者PCI术后发生肾损伤的危险因素（β=0.499-1.171,P〈0.05或〈0.01）。结论：低水平高密度脂蛋白胆固醇是导致冠心病患者PCI术后发生肾功能损伤的危险因素。
Objective： To explore influence of low high density lipoprotein cholesterol （HDL-C） level on kidney function in patients with coronary heart disease （CHD） after percutaneous coronary intervention （PCI）. Methods： A total of 300 CHD patients, who were treated and received PCI in our hospital from Feb 2012 to Jun 2014, were selected. According to HDL-C level, they were divided into normal HDL-C level group （n = 179, HDL-C≥1.04 mmol/ L） and low HDL-C level group （n = 121, HDL-C〈1.04 mmol/L）. Baseline data were compared between two groups, and multi-factor Logistic regression analysis was used to analyze risk factors for kidney injury after PCI. Results： Compared with normal HDL-C level group, there were significant rise in percentages of overweight （30.73% vs. 39.67%）, smoking history （29.05% vs. 41.32%）, myocardial infarction history （35.20% vs. 46.28%）, left ventricular eiection fraction （LVEF） G50% （18.99% vs. 24.79%）, anemia （16.20% vs. 27.27%） and kidney in- jury （12.85% vs. 22.31%） in low HDL-C level group, PG0.05 or G0.01. Multi-factor Logistic regression analysis indicated that age, myocardial infarction history, anemia, LVEFG50%, diabetes mellitus, dosage of contrast agent and low HDL-C level were risk factors for kidney injury in CHD patients after PCI （β = 0. 499-1. 171, P〈0.05 or 〈0.01）. Conclusion： Low HDL-C level is a risk factor for renal function injury in CHD patients after PCI.
出处
《心血管康复医学杂志》
CAS
2015年第6期627-629,共3页
Chinese Journal of Cardiovascular Rehabilitation Medicine
