摘要
目的通过分析肺癌患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平与凝血指标活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(FIB)、D-二聚体(DD)、血小板(PLT)水平的变化,探讨癌症患者炎症反应与凝血指标变化的关系。方法选择65例肺癌患者作为观察组,选取同期50例健康体检人员作为对照组,比较2组受试人员的血清TNF-α、IL-6水平和凝血指标,分析癌症患者炎症反应与凝血功能的相关性。结果对照组血清TNF-α、IL-6水平显著低于各个时期的观察组(P均<0. 05)。对照组FIB、DD浓度显著低于各个时期的观察组(P均<0. 05);对照组APTT、PLT水平显著高于各个时期的观察组(P均<0. 05);对照组PT水平显著低于观察组Ⅲ、Ⅳ期(P均<0. 05),但与观察组Ⅰ、Ⅱ期无统计学差异(P均> 0. 05)。血清TNF-α水平与APTT、PLT呈负相关(γ=-0. 963,P=0. 009;γ=-0. 963,P=0. 009),TNF-α与PT、FIB、DD呈正相关(γ=0. 940,P=0. 017;γ=0. 996,P=0. 000;γ=0. 987,P=0. 002)。血清IL-6水平与APTT、PLT呈负相关(γ=-0. 986,P=0. 002;γ=-0. 993,P=0. 001),IL-6与FIB、DD呈正相关(γ=0. 979,P=0. 004;γ=0. 993,P=0. 001),IL-6与PT无相关性(P> 0. 05)。结论肺癌患者体内存在炎症反应和凝血功能紊乱,且随着临床分期的增加反应加剧,并且其血清炎症因子和凝血指标之间具有相关性。
Objective To explore the relationship between inflammatory response and coagulation index in cancer patients by analyzing the changes of serum tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and thromboplastin(APTT),prothrombin time(PT),fibrin(FIB),D-dimer(DD),platelet(PLT)levels.Methods Selected 65 patients with lung cancer as the observation group.Selected 50 healthy persons who receiving health examination as the control group at the same period.The serum TNF-α,IL-6 levels and coagulation parameters were compared between the 2 groups.To analyze the correlation between inflammatory response and coagulation function in cancer patients.Results The levels of serum TNF-αand IL-6 in the control group were significantly lower than those of the control group(P<0.05).The concentration of FIB and DD in control group was significantly lower than that of observation group(P<0.05).The levels of APTT and PLT in the control group were significantly higher than those of the observation group(P<0.05).The level of PT in the control group was significantly lower than that of the observation groupⅢandⅣ(P<0.05),but there was no significant difference with the observation groupⅠandⅡ(P>0.05).The levels of serum TNF-αwere negatively correlated with APTT and PLT(γ=-0.963,P=0.009;γ=-0.963,P=0.009).TNF-αwas positively correlated with PT,FIB,DD(γ=0.940,P=0.017;γ=0.996,P=0.000;γ=0.987,P=0.002).Serum IL-6 levels were negatively correlated with APTT and PLT(γ=-0.986,P=0.002;γ=-0.993,P=0.001).IL-6 was positively correlated with FIB and DD(γ=0.979,P=0.004;γ=0.993,P=0.001),IL-6 was not associated with PT(P>0.05).Conclusion Lung cancer patients with inflammatory response and coagulation disorders,and with the increase in clinical staging increased,and its serum inflammatory factors and coagulation indicators are related.
作者
李少昆
安生花
郭凤龙
崔丽萍
LI Shaokun;AN Shenghua;GUO Fenglong(Traffic Hospital of Qinghai,Xining,810081)
出处
《实用癌症杂志》
2018年第11期1773-1776,共4页
The Practical Journal of Cancer
