摘要
目的探讨益气除痰方联合化疗对中晚期非小细胞肺癌(NSCLC)患者近期疗效及对患者血清白细胞介素-2(IL-2)、肿瘤坏死因子-α(TNF-α)和免疫功能水平的影响。方法选取2019年1月至2021年1月南京市胸科医院收治的中晚期NSCLC患者86例,依据随机数字表法分为观察组和对照组,各43例。对照组患者给予化疗治疗,观察组患者在化疗基础上服用益气除痰方治疗。2组患者疗程以21 d为1个周期,连续治疗2个周期。比较2组患者近期疗效和生存质量改善情况,治疗前后病灶大小、IL-2、TNF-α和免疫功能变化,及毒副反应发生情况。结果观察组患者总有效率高于对照组(79.07%vs55.81%,P<0.05)。2组治疗后患者病灶较治疗前减小(P<0.05);观察组治疗后患者病灶小于对照组(P<0.05)。观察组患者生存质量提高率高于对照组(83.72%vs60.47%,P<0.05)。2组患者治疗后血清IL-2水平较治疗前升高,而TNF-α水平较治疗前降低(P<0.05);观察组患者治疗后血清IL-2水平高于对照组,而TNF-α水平低于对照组(P<0.05)。观察组患者治疗后CD_(3)^(+)T细胞、CD_(4)^(+)T细胞和CD_(4)^(+)T细胞/CD_(8)^(+)T细胞较治疗前升高(P均<0.05),并且高于对照组(P均<0.05)。观察组患者肝肾异常、骨髓抑制、胃肠道反应、白细胞减少和乏力发生率低于对照组(P均<0.05)。结论益气除痰方联合化疗对中晚期NSCLC患者近期疗效良好,可提高IL-2水平和降低TNF-α水平,并且提高患者免疫功能。
ObjectiveTo evaluate the short-term curative effect of Yiqi Chutan recipe combined with chemotherapy in patients with advanced non-small cell lung cancer(NSCLC)and explore its impact on the serum levels of interleukin-2(IL-2)and tumor necrosis factor-α(TNF-α)and immune function.MethodsA total of 86 patients with advanced NSCLC treated at Nanjing Chest Hospital from January 2019 to January 2021 were selected and divided into either an observation group or a control group using the random number table method,with 43 cases in each group.Both groups were treated with chemotherapy,and the observation group was additionally treated with Yiqi Chutan recipe.The treatment course of the two groups was 21 days as one cycle,and the treatment lasted for two cycles.The short-term efficacy and improvement of quality of life were compared between the two groups.Lesions size,serum levels of IL-2 and TNF-α,the change of immune function,and the incidence of toxicity reaction were also compared.ResultsThe total effective rate in the observation group was higher than that of the control group(79.07%vs55.81%,P<0.05).After treatment,the lesion size was significantly smaller than that before the treatment in both groups(P<0.05),and the lesion size of the observation group was significantly smaller than that of the control group(P<0.05).The rate of quality of life improvement of the observation group was significantly better than that of the control group(83.72%vs60.47%,P<0.05).After treatment,the level of serum IL-2 increased and the level of TNF-αdecreased in both groups(P<0.05);the changes in the levels of serum IL-2 and TNF-αin the observation group were more significantly than those of the control group(P<0.05).After treatment,the CD_(3)^(+)cells,CD_(4)^(+)cells,and CD_(4)^(+)/CD_(8)^(+)rate in the observation group were higher than those before treatment(P<0.05 each)as well as those of the control group(P<0.05 each).Compared with the control group,the incidence of liver and kidney abnormalities,bone marrow suppression,gastroin
作者
杨玖
洪梅
刘志远
朱诺
Yang Jiu;Hong Mei;Liu Zhiyuan;Zhu Nuo(Department of Radiotherapy,Nanjing Chest Hospital,Brain Hospital Affiliated to Nanjing Medical University,Nanjing 210029,China)
出处
《中华临床医师杂志（电子版）》
CAS
北大核心
2021年第12期948-953,共6页
Chinese Journal of Clinicians(Electronic Edition)
