摘要
目的:观察与比较不同手术方式对肺癌根治术患者血清趋化因子及选择素指标表达的影响。方法:选取2017年2月-2019年12月本院收治的90例肺癌根治术患者为研究对象,将其随机分为A组(采取开胸手术)和B组(采取胸腔镜手术),每组45例。比较两组术后不同时间的疼痛程度(VAS评分)、手术前后的血清炎症介质、趋化因子及选择素指标水平。结果:术后6、12、24、72 h,B组的VAS评分均显著低于A组,差异均有统计学意义(P<0.05)。术前两组的血清炎症介质、趋化因子及选择素指标水平比较,差异均无统计学意义(P>0.05);术后1、3、5 d,B组的血清炎症介质、趋化因子及选择素指标水平均显著低于A组,差异均有统计学意义(P<0.05)。结论:胸腔镜肺癌根治术患者围术期的疼痛程度较轻,炎性因子、血清趋化因子及选择素控制较好,临床应用价值较高。
Objective:To observe and compare the influence of different operation methods for serum chemokines and selectin expression of patients with radical resection for lung cancer.Method:A total of 90 patients with radical resection for lung cancer from February 2017 to December 2019 were chosen for the study,and they were randomly divided into group A(open operation)and group B(thoracoscopic operation)with 45 cases in each group.The pain degree(VAS score)at different time after the operation,serum inflammatory mediators,chemokines and selectin expression before and after the operation of two groups were compared.Result:The VAS scores of group B at 6 h,12 h,24 h and 72 h after the operation were significantly lower than those of group A,there were statistically significant differences(P<0.05).The serum inflammatory mediators,chemokines and selectin expression of two groups before the operation were compared,there were no statistically significant differences(P>0.05);the serum inflammatory mediators,chemokines and selectin expression of group B at 1,3 and 5 d after the operation were significantly lower than those of group A,there were statistically significant differences(P<0.05).Conclusion:Patients undergoing thoracoscopic radical resection of lung cancer has less perioperative pain,better control of inflammatory cytokines,serum chemokines and selectin,and higher clinical application value.
作者
朱秣含
ZHU Mohan(The Third People’s Hospital of Yingkou City,Yingkou 115000,China)
出处
《中国医学创新》
CAS
2021年第8期18-21,共4页
Medical Innovation of China
关键词
开胸手术
胸腔镜手术
肺癌根治术
趋化因子
选择素
Open operation
Thoracoscopic operation
Radical resection for lung cancer
Chemokines
Selectin
