摘要
目的评估维生素D缺乏对原发性高血压患者血管内皮功能及血浆肾素活性的影响。方法选取133名接受钙通道阻滞剂或无药物治疗的原发性高血压患者进行了横断面分析。采集患者的空腹血液样品,测定血清维生素D水平及血浆肾素活性(PRA)、血管紧张素II和血浆醛固酮浓度(PAC)。同时,利用血管内皮功能检测仪评估血流介导的血管舒张功能(FMD)。结果入选患者中,有94名(70.7%)患者存在维生素D缺乏。维生素D正常组和维生素D缺乏组在年龄、坐位收缩压、高密度脂蛋白胆固醇(HDL-c)、低密度脂蛋白胆固醇(LDL-c)、维生素D、超敏C反应蛋白(Hs-CRP)、甲状旁腺激素、PRA、FMD指标比较存在统计学差异(P<0.05)。Pearson相关性分析结果显示,维生素D与年龄(r=-0.21,P=0.033)、坐位收缩压(r=-0.22,P=0.035)、Hs-CRP(r=-0.23,P=0.031)、甲状旁腺激素(r=-0.19,P=0.039)、PRA(r=-0.31,P=0.013)和FMD(r=0.35,P=0.010)之间具有相关性。多元逐步线性回归分析显示,血清维生素D与PRA(β=-0.235,P=0.002)存在负相关性,与FMD(β=0.432,P<0.001)存在正相关性。结论维生素D缺乏症在原发性高血压患者中非常普遍,并且维生素D水平与PRA活性及FMD独立相关。
Objective To evaluate the effect of serum 25-hydroxyvitamin D(vitamin D)on vascular endothelial function and renin-angiotensin-aldosterone system in patients with essential hypertension.Methods A cross-sectional analysis was performed on 133 patients treated with calcium channel blockers or no medication in the outpatient department of the hospital from September 2016 to March 2017.The blood samples of the patients were collected,and the serum vitamin D content,plasma renin activity(PRA),angiotensin II,and plasma aldosterone concentration(PAC)were assessed.At the same time,vasodilation function(FMD)was evaluated with the vascular endothelial function detector.Results Among the 133 patients,94(70.7%)had vitamin D deficiency.There were significant differences in age,systolic pressure,HDL-c,LDL-c,vitamin D,Hs-CRP,parathyroid hormone,PRA,and FMD between the normal vitamin D group and the vitamin D deficiency group(P<0.05).Pearson correlation analysis showed that vitamin D had a significant correlation with age(r=-0.21,P=0.033),office systolic blood pressure(r=-0.22,P=0.035),Hs-CRP(r=-0.23,P=0.031),parathyroid hormone(r=-0.19,P=0.039),PRA(r=-0.31,P=0.013),and FMD(r=0.35,P=0.010).The multivariate linear regression analysis showed serum vitamin D had a significant negative association with PRA(β=-0.235,P=0.002)but a significant positive association with FMD(β=0.432,P<0.001).Conclusion Vitamin D deficiency is very common in patients with essential hypertension,and vitamin D level is independently associated with PRA activity and FMD.
作者
李春莉
李玉梅
卢京
孙小军
LI Chun-li;LI Yu-mei;LU Jing;SUN Xiao-jun(Department of Cardiovascular Medicine,People s Hospital of Wenshan Prefecture,Wenshan 663000;Department of Internal Medicine,Yangchun People s Hospital,Yangchun 529600,China)
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2018年第6期865-870,共6页
Journal of Xi’an Jiaotong University（Medical Sciences）
