摘要
目的研究卡托普利片联合珍菊降压片对原发性老年高血压患者的临床疗效。方法将上海市虹口区江湾镇街道社区卫生服务中心诊疗的68例原发性高血压患者随机分为治疗组(34例)和对照组(34例),对照组口服卡托普利片12.5 mg/次,3次/d,疗程4周;治疗组口服卡托普利片,每次12.5 mg,3次/d,同时口服珍菊降压片,0.48 g/次,3次/d,均于每天早餐前服用,4周为1疗程。治疗前后测量患者血压进行疗效分析,同时严密观察患者的不良反应。结果治疗后,两组患者的收缩压和舒张压均有明显改变,且与治疗前相比差异均有统计学意义(P<0.05)。治疗组和对照组收缩压下降幅度分别为14.3%、8.4%,两组比较差异有统计学意义(P<0.05);舒张压下降幅度分别为22.7%、19.3%,两组比较差异有统计学意义(P<0.05)。治疗组和对照组总有效率分别为97.1%、85.3%,两组比较差异有统计学意义(P<0.05)。两组患者均未见严重不良反应。结论卡托普利片联合珍菊降压片治疗老年原发性高血压的临床疗效较好,且不良反应少,值得在社区推广应用。
Objective To observe the efficacy of Captopril Tablets combined with Zhenju Hypotensive Tablets（CT-ZHT） in the treatment of primary hypertension in gerontal patients of Jiangwan Community Health Center of Hongkou District of Shanghai. Methods The elderly patients（68 cases） with primary hypertension were randomly divided into the treatment（34 cases） and control（34 cases） groups. The patients in the control group were given CT 12.5 mg for three times every day during four weeks and the patients in the treatment group were given CT 12.5 mg and ZHT 0.48 g for three times every day for four weeks. Blood pressure was measured before and after treatment.. All the participants were closely observed and recored of any adverse reactions. Results After treatment, the blood pressure was significantly lower than before treatment with significant difference（P〈0.05）. At the end of week 4,The systolic blood pressure of treatment and control groups decreased by 14.3% and 8.4% respectively, with statistically significant difference（P〈0.05）; Diastolic blood pressure decreased by 22.7% and 19.3% respectively, with statistically significant difference（P〈0.05）. The antihypertensive effective rates in the treatment and control groups were 97.1% and 85.3%, respectively. There were obvious differences in the effects of both hypotensive drugs（P0.05）. Blood routine examination, routine urine test, blood lipids, blood glucose, liver and kidney function showed no abnormality. Few adverse reactions were observed in both groups and the difference was no remarkable statistically. Conclusion CT-ZHT in the treatment of primary hypertension has good antihypertensive effect in elderly patients with primary hypertension, producing few side effects and well patient compliance.
出处
《现代药物与临床》
CAS
2014年第3期278-281,共4页
Drugs & Clinic
关键词
卡托普利片
珍菊降压片
高血压
临床疗效
Captopril Tablet
Zhenju Hypotensive Tablet
hypertension
clinical curative effect
