摘要
目的采用乙酸钠为催化剂,对合成阿司匹林的反应体系进行监测研究。方法分别建立阿司匹林和水杨酸在289nm和308 nm处的紫外二阶导数值与浓度的标准工作曲线,实时监测不同温度条件下反应体系中阿司匹林和水杨酸的含量变化情况。结果当控制合成阿司匹林的反应温度分别为45、55、65和75℃时,反应完成的时间约为20、10、4和3 min。结论随着反应温度提高,乙酸钠催化合成阿司匹林反应的时间显著变短。采用紫外吸收及导数光谱法,可以实现对阿司匹林合成过程的监测和判断反应终点。
Objective To research on monitoring synthesis systems of aspirin with sodium acetate as the catalyst.Methods Each standard work curve of aspirin and salicylic acid were established with second derivative value against concentration at the wavelengths of 289 nm and 308 nm.Under different temperatures,the real-time content of aspirin and salicylic acid in synthesis reaction system were monitored.Results When the reaction temperature was 45,55,65 and 75℃,the complete reaction times were about 20,10,4 and 3 min individually.Conclusion The length of the synthesis of aspirin reaction time was significantly shorter with the higher reaction temperature by using sodium acetate as catalyst.The ultraviolet absorption and derivative spectrometry can be achieved on the monitoring and judging aspirin synthesis reaction endpoint.
作者
邵建群
唐静成
徐艳霞
张枫
Shao Jianqun;Tang Jingcheng;Xu Yanxia;Zhang Feng(Experimental Teaching Center,School of Pharmaceutical Sciences,Capital Medical University,Beijing 100069,China)
出处
《首都医科大学学报》
CAS
北大核心
2018年第5期710-714,共5页
Journal of Capital Medical University
基金
北京市教育委员会人才培养质量建设项目(PXM2017_014226_000073)
首都医科大学2015年度校长基金(2015JYY28)~~
关键词
阿司匹林
乙酸钠
紫外吸收光谱
二阶导数光谱
aspirin
sodium acetate
ultraviolet absorption spectrum
second derivative spectrum
