摘要
目的:研究枣庄地区健康人群、胃溃疡患者和胃癌患者的血清胃蛋白酶原的水平。方法:采集128例健康体检者、65例胃溃疡患者、65例胃癌患者的空腹血清,采用化学发光免疫分析法进行血清胃蛋白酶原Ⅰ(PGⅠ)、血清胃蛋白酶原Ⅱ(PGⅡ)的水平测定并计算PGⅠ/PGⅡ比值(PGR)。结果:健康人群中的血清PGⅠ、PGⅡ、PGR中位数男性组高于女性组,随着年龄的增高,PGⅡ水平升高,PGR降低。胃溃疡患者PGⅠ、PGⅡ比对照组明显升高,差异具有显著性(P<0.05),PGR对比差异无显著性(P<0.05),胃癌患者PGⅠ、PGR较对照组明显降低,差异显著(P<0.01)。结论:血清PGⅡ、PGR水平在不同性别和不同年龄组间有着明显的差异;血清PGⅠ、PGⅡ、PGR对胃癌的早期筛查有着重要临床意义。
Objective:To investigate the serum pepsinogen levels among the population of the healthy physical,gastric ulcer,and gastric cancer in Zaozhuang of Shandong province.Methods:The fasting serum was collected from 128 cases of normal controls,65 cases of gastric ulcer and 65 cases of gastric cancer in our hospital.The levels of PGⅠand PGⅡwere detected by CLIA;and the PGⅠ/PGⅡratio(PGR)was calculated.Results:The medians of serum PGⅠ,PGⅡand PGR in the male were higher than the female in healthy population.With the age increasing,the level of serum PGⅡwas increased,but PGR was reduced.The serum PGⅠand PGⅡin gastric ulcer group was obviously higher than the control group,with significant differences(P<0.05);there was no significant difference of PGR(P<0.05).The PGⅡand PGR in gastric cancer group were obviously lower than the control group,with significant differences(P<0.01).Conclusion:PGⅡand PGR levels show significant differences between different genders and different age groups.The PGⅠ,PGⅡand PGR levels in the diagnosis of gastric cancer show important clinical significance.
出处
《中医临床研究》
2018年第22期132-134,共3页
Clinical Journal Of Chinese Medicine
