摘要
目的探讨血清胃蛋白酶原、胃泌素17及幽门螺杆菌(Hp)对老年胃癌前病变诊断的价值。方法选择我院2016年6月~2017年6月期间收治的老年胃癌前病变患者153例作为研究对象,其中慢性萎缩性胃炎67例、浅表性胃炎48例、胃溃疡38例;另选择我院同期健康体检者50例作为对照组。各组研究对象均于清晨采集外周静脉血,分离血清,采用酶联免疫吸附法测定血清胃蛋白酶原(PG)(包括PGⅠ和PGⅡ)和胃泌素17的含量。比较各组血清PGⅠ、PGⅡ、胃泌素17含量和Hp感染阳性率,以及血清PGⅠ、PGⅡ、胃泌素17含量与Hp感染联合诊断的效能。结果慢性萎缩性胃炎组、浅表性胃炎组和胃溃疡组血清PG I、PG II和胃泌素17含量高于对照组,差异有统计学意义(P<0.05);慢性萎缩性胃炎组和浅表性胃炎组血清PG I、PG II和胃泌素17含量比较,差异无统计学意义(P>0.05);胃溃疡组血清PGⅠ、PGⅡ和胃泌素17含量高于慢性萎缩性胃炎组和浅表性胃炎组,差异有统计学意义(P<0.05)。慢性萎缩性胃炎组、浅表性胃炎组和胃溃疡组Hp感染阳性率高于对照组,差异有统计学意义(P<0.05);慢性萎缩性胃炎组和浅表性胃炎组Hp感染阳性率比较,差异无统计学意义(P>0.05);胃溃疡组Hp感染阳性率高于慢性萎缩性胃炎组和浅表性胃炎组,差异有统计学意义(P<0.05)。胃癌前病变血清PGⅠ、PGⅡ、胃泌素17含量与Hp感染联合诊断的灵敏度和特异度高于各项单独检测。结论老年胃癌前病变患者血清PGⅠ、PGⅡ和胃泌素17含量升高,Hp感染阳性率高,联合诊断具有较高灵敏度和特异度,具有重要研究价值。
Objective To investigate the value of serum pepsinogen, gastrin 17 and Helicobacter pylori （Hp） in the diagnosis of pre- cancerous lesions of the stomach in elderly patients. Methods 153 elderly patients with gastric precancerous lesions were selected in our hospital between June 2016 and June 2017, including 67 chronic atrophic gastritis patients, 48 superficial gastritis patients, and 38 gastric ulcer patients. Another 50 physical examination persons were selected as control. All samples were collected fi＇om peripheral venous blood, separation of serum, serum PG [including pepsinogen I （PG I ） and pepsinogen Ⅱ （PG Ⅱ）] and gastrin 17 in the morning. Compare the serum PG I, PG Ⅱ and gastrin 17 levels, and the positive rate of Hp infection of patients between two groups. Results The serum PG I, PG Ⅱand gastrin 17 levels of patients in chronic atrophic group, superficial gastritis group and gastric ulcer group were higher than in con- trol group （P 〈 0.05）. There were no significant differences in serum PG I , PG Ⅱ and gastrin 17 levels between chronic atrophic group and superficial gastritis group （P〉0.05）. However, the serum PG I, PG Ⅱ and gastrin 17 levels of patients in gastric ulcer group was higher than in chronic atrophic group and superficial gastritis group （P 〈 0.05）. The positive rate of Hp infection in chronic atrophic gastritis group, superficial gastritis group and gastric ulcer group was higher than in control group （P 〈 0.05）. It was also higher in gastric ulcer group than in chronic atrophic gastritis and superficial gastritis （P 〈 0.05）. Yet it showed no significant difference between chronic atrophic gastritis group and superficial atrophic gastritis group （P〉0.05）. The sensitivity and specificity of serum PG, I, PG Ⅱ, gastrin 17 and Hp detection in combination in the diagnosis of gastric precancerous lesions were higher than those of the single detection. Conclusion The serum levels of PG I, PG Ⅱ, gastrin 17 and the positive rate
作者
王春芳
刘兵
孙光
徐瑜杰
彭勃
WANG Chunfang;LiU Bing;SUN Guang;XU Yujie;PENG Bo(Department of Gastrointestinal Surgery,Haikou People＇ s Hospital,Haikou,Hainan,570208,China)
出处
《肿瘤药学》
CAS
2018年第4期588-592,共5页
Anti-Tumor Pharmacy
基金
海南省自然科学基金(811215)
