摘要
目的探讨血清胃蛋白酶原（PG）含量动态变化规律及其意义。方法对辽宁庄河胃癌高发区444例胃癌筛查受检者，在初检和随访时，分别利用酶联免疫吸附试验（ELISA）方法进行血清PGⅠ、PGⅡ含量检测，并计算PGⅠ／Ⅱ比值；利用胃镜及胃黏膜组织病理学检查进行胃疾病诊断；利用胃黏膜HE染色和幽门螺杆菌（Hp）抗体检测两种方法联合判定Hp感染情况。结果（1）以≤40岁、41—50岁、51—60岁和≥61岁进行年龄分组，各年龄组中仅51—60岁组，随访6个月PGⅡ变化率（0．84）显著低于12个月（1．22，P=0．019）和30个月组（1．24，P=0．004），PGⅠ／Ⅱ比值变化率（1．09）显著高于后两组（0．75、P=0．027，0．69、P=0．001）。（2）浅表性胃炎（SG）减轻组随访6个月PGⅠ变化率（0．69）显著低于12个月（0．97，P=0．002）；萎缩性胃炎（AG）减轻组随访6个月PGⅠ／Ⅱ变化率（1．13）显著高于30个月（0．75，P=0．042）。（3）SG→NOR（正常）组PGⅠ变化率（0．94）显著高于SG→AG组（0．79，P=0．022）；AG→NOR组PCⅠ、PGⅡ变化率（0．43、0．60）均显著低于AG→SG组（0．87、P=0．000，1．11、P=0．010）。（4）Hp阴性→阳性组PGⅠ变化率（0．94）显著高于阴性→阴性组（0.81，P=0．026）；阳性→阴性组PGⅠ、PGⅡ变化率（0．74，0．86）显著低于阳性→阳性组（0．93、1．15，均P=0．000），PGⅠ／Ⅱ比值变化率（0．90）显著高于后者（0．70，P=0．022）。结论血清PG变化率与随访时间、受检者胃疾病性质及Hp感染状态的变化密切相关。血清PG含量动态检测可用于胃癌高危人群监测。
Objective To investigate the dynamic changes of serum pepsinogen （PG） among the high risk populations of gastric cancer. Methods Peripheral blood samples were collected from 444 subjects in the high risk areas of gastric cancer in Zhuanghe county, Liaoning province, who underwent screening of gastric cancer, 225 males and 219 females, aged 48.31 （21-76） . ELSA was used to measure the serum PG Ⅰ and PGⅡ. The PG Ⅰ / Ⅱ ratio was calculated. Gastroscopy was conducted to take 4 pieces of biopsy specimens from each subject to undergo pathological examination. Histological examination and serum Hp- IgG antibody determination by ELISA were performed to detect the infection of Helicobacter pylori （Hp）. The above mentioned examinations were carried out at the first screening and 6, 12, and 30 months later during follow-up. Results （ 1 ） In the age group 51-60 , the percentage change in PGⅡ of 6-month follow-up was 0.84, significantly lower than those of the 12-month follow-up （1.22, P =0.019） and 30-month follow-up （ 1.24, P = 0. 004 ）, and the percentage change in PG Ⅰ / Ⅱ of the 6-month follow-up was 1. 09, significantly higher than those of the 12-month follow-up （ 0. 75, P = 0. 027 ） and 30-month follow-up （0. 69, P =0.001）. However, there were no significant differences in serum PG Ⅰ , serum PGⅡ , and PG Ⅰ / Ⅱ ratio in other age groups. （2） The percentage change in serum PG Ⅰ of the patients of superficial gastritis （SG） with mitigation of the 6-month follow-up was 0.69, significantly lower than that of the 12- month follow-up （0.97, P = 0.002）. The percentage change in PG Ⅰ / Ⅱ of the patients of atrophic gastritis （AG） with mitigation of the 6-month follow-up was 1. 13, significantly higher than that of the 12-month follow-up （0.75, P =0.042）. （3） The percentage change in PG Ⅰ of the SG→NOR （normal） group was 0.94, significantly higher than that of the SG→AG group （0.79, P = 0. 002）. The percentage changes in PG Ⅰ and
出处
《中华医学杂志》
CAS
CSCD
北大核心
2006年第40期2826-2830,共5页
National Medical Journal of China
基金
国家"十五"科技攻关项目基金资助[2001BA703B06(B)
2004BA703B04-02]
关键词
胃蛋白酶原
胃肿瘤
螺杆菌
幽门
Pepsinogens
Stomach neoplasms
Helicobacter pylori
