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MAGE-A9和Ki-67在乳腺癌的表达及意义

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摘要 目的 探讨分析MAGE-A9和增殖细胞核抗原(Ki-67)在乳腺癌的表达及与乳腺癌发生、发展的关系。方法 2014年10月至2016年10月选取69例乳腺癌组织及20例癌旁组织作为研究对象,采用免疫组化方法检测MAGE-A9和Ki-67的表达,并结合临床资料进行分析。结果 MAGE-A9和Ki-67在乳腺癌组织中的阳性表达率均明显高于癌旁组织,差异均有统计学意义(P<0.05)。乳腺癌组织中MAGE-A9和Ki-67的表达均与乳腺癌组织学分级具有相关性,而与患者年龄、肿瘤大小、临床分期及淋巴结转移等无关。MAGE-A9和Ki-67在乳腺癌的表达无相关性。结论 MAGE-A9和Ki-67在乳腺癌的高表达提示二者在乳腺癌的发生、发展中发挥了促癌作用,二者的联合检测或许可作为临床诊断的重要参考指标。MAGE-A9在乳腺癌中高表达,提示其可能是乳腺癌的相关性抗原,在免疫治疗中或许会发挥重要作用。
出处 《重庆医学》 CAS 2018年第A01期274-276,共3页 Chongqing medicine
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