摘要
利用阳离子表面活性剂十六烷基三甲基溴化铵(CTAB)为模板剂,正硅酸乙酯(TEOS)为硅源,采用水热合成法、酸液萃取法制备介孔二氧化硅纳米颗粒(MSNs)。氮气吸附—脱附实验结果表明,所制备的MSNs为典型的介孔结构,孔径分布均匀,适合于药物载带。抗肿瘤药物姜黄素(Cur)的载带与释放表明MSNs为典型的pH响应药物载体,在pH=7.4时Cur的包封率和载药率分别高达50%和15%左右,而在pH=5.0的环境中则快速释放药物。
The mesoporous silica nanoparticles(MSNs)are prepared by adopting cetyl trimethyl ammonium bromide(CTAB)template and tetraethyl orthosilicate(TEOS)as silicon source.The N2 adsorption/desorption isotherms demonstrated the MSNs exhibit typical IV-typed isotherms with H1-hysteresis loops,which are the properties of typical mesoporous materials.The anti-cancer drug curcumin(Cur)storage/release properties were demonstrated to be pH-responsive,in which,the Cur encapsulation efficiency(EE,%)and drug loading content(DLC,%)could up to over 50%and 15%at pH7.4,respectively.However,the drug release might be beneficial at the reduced pH of 5.0.
作者
梁旭华
任素娟
吴美妮
LIANG Xu-hua;REN Su-juan;WU Mei-ni(School of Biopharmaceutical and Food Engineering,Shangluo University,Shangluo 726000,Shaanxi)
出处
《商洛学院学报》
2018年第2期63-66,73,共5页
Journal of Shangluo University
基金
国家级大学生创新创业训练计划项目(201711396011)
关键词
介孔二氧化硅
水热合成法
PH响应
纳米药物输送系统
mesoporous silica nanoparticles
hydrothermal synthesis
pH-responsive
nanopartiele drug delivery system
