摘要
纳米药物缓释系统由于具有抗药性小、毒副作用低、治疗效果好等优点,得到研究者们的广泛关注。首先以双键修饰的介孔二氧化硅纳米粒为基质,叶酸和丙烯酰基-β-环糊精单体(β-CD-A)为功能单体,N,N′-亚甲基双丙烯酰胺(MBA)为交联剂,通过自由基聚合法制备了叶酸靶向药物载体MSNs@P(CD-co-FA)。然后采用浸渍法对姜黄素进行载药吸附。结果表明:MSNs@P(CD-co-FA)的最佳载药浓度为300mg/L,对姜黄素的平衡吸附量为81.7mg/g,最佳载药时间为10h。体外释药结果显示,MSNs@P(CD-co-FA)在24h时累计释放率为11.24%。
Nano-drug sustained release system has been widely concerned by researchers because of its advantages of small drug resistance,low toxic and side effects,and good therapeutic effect.In this study,folic acidtargeted drug carrier MSNs@P(CD-co-FA)was prepared by free radical polymerization using double bond modified mesoporous silica nanoparticles as matrix,folic acid and acryloyl-β-cyclodextrin monomer(β-CD-A)as functional monomers,and N,N′-methylenebisacrylamide(MBA)as crosslinking agent.Then,the drug-loaded adsorption of curcumin was performed by impregnation method.The results showed that the optimal drug loading concentration of MSNs@P(CD-co-FA)was 300mg/L,the equilibrium adsorption capacity of curcumin was 81.7mg/g,and the best drug loading time was 10h.The in vitro release results revealed that the cumulative release rate of MSNs@P(CD-co-FA)was 11.24%at 24h.
作者
陈静宜
张倩
尚宏周
乔宁
孙晓然
于德红
Chen Jingyi;Zhang Qian;Shang Hongzhou;Qiao Ning;Sun Xiaoran;Yu Dehong(College of Chemical Engineering,North China University of Science and Technology,Tangshan 063000;College of Materals Science and Engineering,North China University of Science and Technology,Tangshan 063000;College of Jitang,North China University of Science and Technology,Tangshan 063000)
出处
《化工新型材料》
CAS
CSCD
北大核心
2023年第S01期136-140,145,共6页
New Chemical Materials
基金
国家级大学生创新创业训练项目(202010081002)
河北省教育厅项目(JYG2019003)
唐山市基础创新团队项目(21130201D)
关键词
叶酸靶向
介孔二氧化硅
药物载体
缓释
folic acid targeting
mesoporous silica
drug carrier
sustained release
