摘要
目的分析经尿道前列腺电切联合内分泌治疗晚期前列腺癌膀胱出口梗阻疗效。方法选择该院2016年3月—2017年3月间该院晚期前列腺癌膀胱出口梗阻患者98例,按照不同治疗方法将其分为实验组和对照组,每组患者49例,对照组患者是以药物治疗为主,实验组则采取经尿道前列腺电切联合内分泌治疗。当两组患者完成分别治疗后,在术后12个月进行剩余尿量与最大尿流率、IPSS评分和PSA的分析,同时观察两组患者疾病死亡与进展人数。结果临床治疗后,实验组剩余尿量(27.1±15.1)mL,最大尿流率(11.6±3.5)mL/s,IPSS评分(8.4±2.5)分,PSA(4.8±1.8)ng/L,对照组剩余尿量(127.2±46.2)mL,最大尿流率(5.1±1.7)mL/s,IPSS评分(23.6±5.8)分,PSA(5.7±2.3)ng/L,组间各项数据对比差异有统计学意义(P<0.05);实验组患者中,2例患者血糖升高,4例患者发生电切综合征症状,在进行针对性处理后,患者病情得到明显缓解,在患者围手术期内未出现死亡病例。术后6个月3例患者尿道狭窄,2例患者定期扩张,1例患者应进行手术干预。另外,4例患者发生不同程度尿路感染,在进行对症处理之后已经好转。对照组患者进行治疗后,其死亡率为18.3%(9/49),组间对比差异有统计学意义(P<0.05)。结论对晚期前列腺癌膀胱出口梗阻患者进行临床治疗时,经尿道前列腺电切联合内分泌治疗效果比较理想,能够有效提升患者尿流率,并实现IPSS评分的下降等,使患者生活质量得到显著改善,具有理想治疗效果。
Objective To analyze the curative effect of transurethral resection of prostate combined with endocrine in treatment of advanced prostatic carcinoma bladder outlet obstruction.Methods 98 cases of patients with advanced prostatic carcinoma bladder outlet obstruction admitted and treated in our hospital from March 2016 to March 2017 were selected and divided into two groups according to different treatment methods with 49 cases in each,the control group mainly used the drugs,while the experimental group used the transurethral resection of prostate combined with endocrine,and the RUV,Qmax,IPSS score and PSA of the two groups in 12 months after treatment were analyzed,at the same time,the morality and disease progression number of the two groups were observed.Results After treatment,the differences in the RUV,Qmax,IPSS score and PSA between the experimental group and the control group were statistically significant,[(27.1±15.1)mL,(11.6±3.5)mL/s,(8.4±2.5)points,(4.8±1.8)ng/L vs(127.2±46.2)mL,(5.1±1.7)mL/s,(23.6±5.8)points,(5.7±2.3)ng/L],(P<0.05),in the experimental group,there were 2 cases whose blood glucose increased,and 4 cases with TURP syndrome,after the targeted treatment,the diseases of patients were obviously relieved,during the perioperative period,there were no death cases,in 6-month after surgery,there were 3 cases with urethrostenosis,2 cases with regular expansion,besides,4 cases were with different degrees of urinary tract infections,and were improved after the systematic treatment,after treatment,the mortality in the control group was 18.3%(9/49),and the difference was statistically significant(P<0.05).Conclusion The effect of transurethral resection of prostate combined with endocrine in treatment of advanced prostatic carcinoma bladder outlet obstruction is ideal,which can effectively improve the Qmax and make the IPSS score decrease,obviously improve the quality of life,and the treatment effect is ideal.
作者
靳丕东
佟发春
JIN Pi-dong;TONG Fa-chun(Department of Urinary Surgery,Yuxi People’s Hospital,Yuxi,Yunnan Province,653100 China)
出处
《系统医学》
2017年第24期107-109,共3页
Systems Medicine
关键词
经尿道前列腺电切
内分泌治疗
晚期前列腺癌
膀胱出口梗阻
Transurethral resection of prostate
Endocrine treatment
Advanced prostatic carcinoma
Bladder outlet obstruction
