摘要
目的探究经尿道等离子前列腺电切术联合睾丸切除术治疗中晚期前列腺癌的临床疗效及对前列腺特异抗原水平的影响。方法回顾性分析2012年6月至2015年6月间收治的120例中晚期前列癌患者的临床资料,采取随机数字表法将患者分为试验组和对照组,每组60例。试验组患者均采用经尿道等离子前列腺电切术联合睾丸切除术治疗,对照组患者均采用常规手术行前列腺和睾丸联合切除术,对比两组患者治疗前后国际前列腺症状评分（IPSS）、前列腺特异抗原（PSA）、最大尿流率（MFR）、残余尿量、前列腺体积及生活质量。结果治疗后,试验组患者较对照组患者的IPSS评分降低,血清PSA水平降低,MFR升高,剩余尿量减少,前列腺体积缩小,差异均有统计学意义（P〈0.05）。与对照组患者治疗后比较,试验组患者的躯体功能、角色功能、情绪功能、认知功能、社会功能及总体健康状况评分均明显提高,差异均有统计学意义（P〈0.05）。与对照组比较,试验组患者手术治疗后排尿困难症状明显缓解,恢复自主排尿率高（96.7%和80.0%）,发生尿失禁率低（0.0%和8.3%）,差异均有统计学意义（P〈0.05）。试验组患者随访6-24个月,56例患者仍带瘤生存。对照组患者随访5-25个月,46例患者目前仍带瘤生存。结论采用经尿道等离子前列腺电切术联合睾丸切除术治疗中晚期前列腺癌的临床疗效显著,血清PSA水平降低,显著改善了患者的生活质量,值得推广与应用。
Objective To explore and analyze Clinical effect of transurethral resection of prostate combined with testicular resection for the treatment of advanced prostate cancer and its effect on the level of prostate specific antigen. Methods The clinical data of 120 patients with advanced prostate cancer treated in the People＇s hospital of Shan Dong province Lin Qu county from June 2015 to June 2012 were retrospectively analyzed. Patients were randomly divided into experimental group and control group,60 cases in each group. The patients in the experimental group were treated by transurethral resection of the prostate and testicular resection,and the control group were treated with the conventional operation. The International Prostate Symptom Score（ IPSS）,prostate specific antigen（ PSA）,maximum urinary flow rate（ MFR）,residual urine volume,prostate volume and quality of life were compared between the two groups before and after treatment. Results After treatment,the patients in the experimental group compared with the control group,the IPSS score and serum PSA level were decreased,MFR was increased,residual urine volume was reduced,prostate volume was decreased,all with statistical differences（ P〈0. 05）. After treatment,compared with the control group,the scores of physical function,role function,emotional function,cognitive function,social function and overall health status of the patients in the experimental group were significantly improved,all with statistical difference（ P〈0. 05）. Compared with the control group,the experimental group had significantly relieved the symptoms of urinary incontinence after surgical treatment,the recovery of spontaneous urination rate was higher（ 96. 7% vs 80. 0%）,the incidence of urinary incontinence was lower（ 0. 0% vs 8. 3%）,all with statistical differences（ P〈0. 05）. The patients in the experimental group were followed up for 6 to 24 months,56 patients are still living with tumor. The patients in control group were followed up for 5 to 25 mo
出处
《中国肿瘤临床与康复》
2016年第3期315-318,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
前列腺肿瘤
经尿道等离子前列腺电切术
睾丸切除术
前列腺特异抗原
治疗结果
Prostate neoplasms
Transurethral resection of the prostate
Testicular resection
Prostate specific antigen
Treatment outcome
