摘要
目的探讨利培酮治疗首发精神分裂症患者所致催乳素水平异常与代谢综合征的关联性及最佳干预时点。方法使用利培酮治疗的首发精神分裂症患者,于治疗起始、治疗第1月、2月、3月、6月末进行代谢综合征指标、催乳素水平的检测以及进行PANSS评分。结果首发精神分裂症患者,服用利培酮治疗后,随着时间的延续,患者的PANSS评分总分显著下降(P<0.01),治疗6月末总体有效率为90.825%;痊愈5例,占15.625%;代谢综合征的发生率为18.75%;治疗3月末催乳素升高最为显著,催乳素异常比率最高,占90.63%,3月后催乳素水平逐渐下降,6月末高催乳素血症发生率为75%;6例发生代谢综合征患者与未发生代谢综合征患者的血清催乳素进行比较,差异无统计学意义(F=0.98,P=0.329)。结论本研究提示使用利培酮治疗的首发精神分裂症患者所致的血清催乳素水平与代谢综合征尚无关联性;结合本研究结果,建议在治疗第6月末对催乳素异常患者进行预期干预。
Objective To investigate the relativity between anomaly level of prolactin in the treatment of the first episode schizophrenia patients and metabolic syndrome after using risperidone,and to evaluate its optimum intervention times.Methods The first episode schizophrenia patients were treated with risperidone for half a year,and then to measure the index of metabolic syndrome and the level of prolactin,and to score the PANSS at the very beginning and at the end of the 1st,2nd,3rd and 6th month during the treatment.Results After treatment the total scores of the PANSS lowered significantly(P<0.01).The overall effective treatment of the study group were 90.825%at the end of the 6th month;5 cases were cured accounting for 15.625%.The incidence rate of metabolic syndrome was 18.75%.At the end of the 3rd month,the level of prolactin increased significantly and the incidence rate of anomaly prolactin was the highest accounting for 90.63%.After 3 months,the level of prolactin lowered gradually while the incidence rate of hyperprolactinemia was 75%at the end of the 6th month.To compare the prolactin of the two groups,there was no statistical significance between the 6 cases who have suffered metabolic syndrome and those who haven’t.Conclusion The research suggests that there is no certain relativity between the level of serum prolactin andmetabolic syndrome after using risperidone.Having combined the results of the research,the researchers suggest intervening treatment in advance at the end of the 6th month.
作者
高兰
王相立
王婷婷
张泽花
崔付新
徐春梅
GAO Lan;WANG Xiang-li;WANG Ting-ting;ZHANG Ze-hua;CUI Fu-xin;XU Chun-mei(Linyi City mental health center,Linyi 276005,China)
出处
《山东医学高等专科学校学报》
2018年第1期32-36,共5页
Journal of Shandong Medical College
基金
临沂市科技发展计划项目(201717068)
