摘要
目的探讨阿立哌唑对精神分裂症患者应用氨磺必利后出现高催乳素血症的疗效。方法对精神分裂症患者以氨磺必利治疗后催乳素水平≥30 ng/L者纳入对照研究,氨磺必利继续原有剂量,合并阿立哌唑或溴隐亭治疗各8周,测定血清催乳素浓度,并观察女性患者闭经、泌乳等临床症状变化。结果阿立哌唑和溴隐亭治疗均可降低患者血清催乳素浓度(P<0.01);二者无统计学差异(P>0.05);男患者治疗前与治疗第4周末PRL差值显著高于女患者(t=3.251,P<0.01);两药均可改善部分女性患者闭经、溢乳现象。结论阿立哌唑可用于治疗氨磺必利所致的精神分裂症患者的高催乳素血症。
Objective To explore the efficacy of aripiprazole on the treatment of hyperprolactinemia for schizophrenics induced by amisulpride.Methods The schizophrenia patients whose prolactin levelswere above 30ng / L after receivedthe treatment of amisulpride were enrolled into the study.The dose of amisulpride were remained unchanged,and combined with aripiprazole or bromocriptine for 8 weeks.The prolactin concentrations in serum were examined,and observe the clinical symptoms changes for female patients,such as amenorrhea and galactorrhea.Results Both aripiprazole and bromocriptine can reduce the concentration of PRL for patients（P 0.01）;Differences between aripiprazole and bromocriptine present no statistically significant（P 0.05）;The Dvalue of PRL for male patients was more than that for famale patients（t = 3.251,P 0.01）.Both aripiprazole and bromocriptine canrelieveamenorrhea and galactorrhea for some female patients;Conclusions Aripiprazole can be applicated in hyperprolactinemia for schizophrenics induced by amisulpride.
出处
《齐齐哈尔医学院学报》
2013年第16期2350-2352,共3页
Journal of Qiqihar Medical University
