摘要
目的分析重症医学科肺部感染患者肺泡灌洗液病原菌分布及其耐药情况,以指导临床抗菌药物使用。方法回顾性分析2016年6月～2017年5月重症医学科肺部感染患者肺泡灌洗液分离的细菌培养结果及耐药性分析。采用WHONET5.4软件进行药敏结果统计。结果共分离出非重复菌株137株,革兰阴性菌共122株,占比89.1%,以鲍曼不动杆、铜绿假单胞菌、肺炎克雷伯菌为主,分别占24.1%、21.9%、14.6%。革兰阳性菌菌株共15株,占比10.9%,以金黄色葡萄球菌为主,占比7.3%,对万古霉素及替考拉宁敏感率为100.0%。结论重症医学科肺部感染患者肺泡灌洗液的主要病原菌为革兰阴性菌,细菌多重耐药现象明显,开展监测及合理用药是控制感染和耐药菌出现的关键。
Objective To analyze the distribution and drug resistance of alveolar lavage fluid in patients with pulmonary infection in the Department of Critical Care Medicine to guide the clinical use of antibacterial drugs.Methods The bacterial culture results and antibiotic resistance of pulmonary alveolar lavage fluid isolated from patients with pulmonary infection in the Department of Critical Care Medicine from June 2016 to May 2017 were retrospectively analyzed.WHONET5.4 software was used for drug susceptibility results statistics.Results A total of 137 non-repetitive strains were isolated,of which 122 strains were Gram-negative bacteria,accounting for 89.1%,mainly including Bauman immobilized rods,Pseudomonas aeruginosa and Klebsiella pneumoniae,accounting for 24.1%,21.9%and 14.6%,respectively.There were a total of 15 strains of Gram-positive bacteria(10.9%),mainly for Staphylococcus aureus,accounting for 7.3%,with 100.0%sensitive rate to vancomycin and teicoplanin.Conclusion The main pathogen of pulmonary alveolar lavage fluid in patients with pulmonary infection in Department of Intensive Care Unit is Gram-negative bacteria.Bacterial multi-drug resistance is obvious.Monitoring and rational drug use is the key to controlling infection and emergence of drug-resistant bacteria.
作者
俞国峰
严一核
应利君
YU Guofeng;YAN Yihe;YING Lijun(Department of Critical Care Medicine,Shaoxing People's Hospital,Shaoxing 312000,China)
出处
《中国现代医生》
2018年第7期89-92,共4页
China Modern Doctor
基金
浙江省医药卫生科技计划项目(2016KYB308)
关键词
重症医学科
肺泡灌洗液
病原菌
耐药性
Department of Intensive Care Unit
Alveolar lavage fluid
Pathogen
Drug resistance
