摘要
目的了解肺泡灌洗液的病原菌分布及耐药性,为临床合理用药提供依据。方法采用美国MicroscanAutoscan-4微生物分析仪对细菌作鉴定及药敏试验。结果病原菌中革兰阴性杆菌占94.0%,革兰阳性球菌占6.0%;病原菌主要来源于神经外科、ICU和呼吸科;嗜麦芽寡养单胞菌对亚胺培南天然耐药,其他4种革兰阴性杆菌对亚胺培南耐药率为0～15.2%,大肠埃希菌、肺炎克雷伯菌产超广谱β-内酰胺酶(ESBLs)阳性率为45.6%、42.9%;革兰阳性球菌对万古霉素耐药率为0,耐甲氧西林金黄色葡萄球菌(MRSA)检出率为56.5%。结论肺泡灌洗液的主要病原菌为革兰阴性杆菌,细菌多药耐药现象严重,合理用药是控制感染的关键。
OBJECTIVE To explore the distribution and the drug resistance of pathogenic bacteria from bronchoalve olar lavage fluid so as to provide evidence for clinical reasonable use of antibiotics. METHODS The identification and drug susceptibility testing for the bacteria were performed using Microscan Autoscan4 microbial analyzer from America. RESULTS Gramnegative bacilli accounted for 94.0%, and grampositive cocci accounted for 6.0%. The pathogens were mainly isolated from the department of neurosurgery, ICU, and respiratory department. Stenotro phomonas maltophilia was naturally resistant to imipenem, but the drug resistance rates of the four other gram negative bacilli to imipenem varied from 0 to 15. 2%. The positive rates of extended spectrumMactamase （ESBLs）producing Escherichia coli and Klebsiella pneumoniae were 45.6% and 42.9%, respectively; the drug resistance rate of grampositive cocci to vancomycin was 0; the detection rate of methicillinresistant Staphylococ cus aureus （MRSA）was 56.5 %. CONCLUSION The main pathogenic bacteria iselated from bronchoalveolar lavage fluid are gramnegative bacilli with severe multidrugresistance, and reasonable use of antibiotics is the crucial in the control of infection.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2012年第7期1515-1517,共3页
Chinese Journal of Nosocomiology
关键词
肺泡灌洗液
病原菌
分布
耐药性
Bronchoalveolar lavage fluid Pathogenic bacteria Distribution Drug resistance
