摘要
目的探讨联合小剂量氨磺必利对慢性精神分裂症患者阴性症状及认知功能的影响,为精神分裂症阴性症状的药物治疗提供参考。方法选取2015年3月-2016年3月在广州市民政局精神病院住院的慢性精神分裂症患者36例,均符合《国际疾病分类(第10版)》(ICD-10)精神分裂症诊断标准。按照随机数字表法分为研究组和对照组各18例。两组均接受第一代抗精神病药(氯丙嗪或氯氮平)治疗,研究组在此基础上联用小剂量氨磺必利(100 mg/d),两组均治疗12周。于治疗前和治疗第2、4、8、12周采用阳性和阴性症状量表(PANSS)评定疗效,于治疗前和治疗第12周采用威斯康星卡片分类测验(WCST)、连线测试(TMT)和Stroop色词测验(CWT)评定认知功能,于治疗后采用副反应量表(TESS)评定安全性。结果治疗第4周,研究组情绪退缩、情感交流评分均较治疗前低(P均<0.05);治疗第12周,研究组情感迟钝、情绪退缩、情感交流、被动淡漠、交流困难的评分均较治疗前低(P均<0.01),研究组完成总应答数(RA)、持续错误数(RPE)、TMT-A、TMT-B、CWT-A、CWT-B与治疗前比较差异均有统计学意义(P均<0.05),两组不良反应比较差异均无统计学意义(P均>0.05)。结论联合小剂量氨磺必利对慢性精神分裂症患者阴性症状及认知功能均有效,安全性与单用原抗精神病药物相当。
ObjectiveTo explore the effect of combined small dose amisulpride with other regular treatment on the negative symptoms and cognitive function of patients with chronic schizophrenia,which was to provide references to drug therapy.MethodsFrom March2015to March2016,36cases of patients with chronic schizophrenia who met the diagnostic criteria of International Classification of Diseases,tenth edition(ICD-10)were selected from the Civil Affairs Bureau Mental Hospital in Guangzhou.There were18cases in the study group and the control group according to the random number table method.Both groups were treated with first-generation antipsychotics(chlorpromazine or clozapine),while the study group also been treated combine with a small dose of amisulpride(100mg/d).Both two groups were treated for12weeks.Before and after treatment for2,4,8,12weeks,Positive and Negative Syndrome Scale(PANSS)was used to evaluate the curative effect.The Wisconsin Card Sorting Test(WCST),Trail Making Test(TMT)and Color Word Test(CWT)were used to assess cognitive function before and after treatment.The safety was assessed with Treatment Emergent Symptom Scale(TESS)after treatment.ResultsAt the4th week of the treatment,the emotional withdrawal and emotional communication scores of the study groups were lower than before treatment(P<0.05).After treatment for12weeks,the emotional retardation,emotional withdrawal,emotional communication,passive indifference and communication difficulties scores were lower than before treatment(P<0.01).The completed the total responses(RA),persistent error number(RPE),TMT-A,TMT-B,CWT-A,CWT-B were significantly different compared with before treatment(P<0.05).There was no statistically significant difference between the adverse reactions of the two groups.ConclusionThe combination of small dose of amisulpride is effective for the negative symptoms and cognitive function of chronic schizophrenic patients,and the safety is comparable with that of the monoclonal antipsychotics.
作者
傅春恋
李雪晶
李素君
Fu Chunlian;Li Xuejing;Li Sujun(Civil Affairs Bureau Mental Hospital in Guangzhou,Guangzhou510430,China)
出处
《四川精神卫生》
2017年第5期436-440,共5页
Sichuan Mental Health
关键词
氨磺必利
慢性精神分裂症
阴性症状
认知功能
Amisulpride
Chronic schizophrenia
Negative symptoms
Cognitive function
