期刊文献+

p-mTOR在胃癌组织中的表达及临床意义

Expression and Significance of p-mTOR in the Tissue of Gastric Carcinoma
下载PDF
导出
摘要 目的探讨p-m TOR的表达水平与胃癌发生的关系。方法选择2014年3月—2016年2月于包头市肿瘤医院经手术根治切除的胃癌标本,采用免疫组织化学法检测60例胃癌组织及40例癌旁胃组织中p-m TOR蛋白水平的表达情况。结果 pm TOR蛋白在胃癌组织中的表达水平高于癌旁组织,差异有统计学意义。结论 p-m TOR在胃癌组织中过度表达可能是胃癌发生的机制之一。 Objective To investigate relationship between the expression levels of p-m T O R and gastric carcinom a Methods Choose in March 2014 to February 2016 in baotou tum or hospital after the surgery, radical resection of gastric cancer specim ens. im m uneohistochemistry was used to determ ine the expression levels of p-m T O R in 60 cancerous tissues and 40 paracancerous tissues. Results The expression level of p-m T O R wras m arkedly higher in the gastric carcinom a tissues than in the paracancerous tissues. Conclusions Overexpression of p-m T O R in gastric cancer may be one of the im portant m echanism s of gastric cancer.
作者 汪星星 韩丽红 闫斌 于跃利 WANG Xing-xing;YU Yue-li;HAN Li-hong;YAN Bin(Baotou Medical C〇nege,Baotou, inner Mongolia, 014060 China;First Affiliated Hospital of Baotou Medical College Second Department of General Surgery,Baotou, lnner Mongolia, 014010 China)
出处 《世界复合医学》 2016年第1期24-26,共3页 World Journal of Complex Medicine
基金 包头市科技计划项目(Wsjj2015073) 内蒙古自治区高等学校科学研究项目(NJZY16204) 包头医学院博士启动基金项目(BSJJ201605)
关键词 胃癌 磷酸化雷帕霉素靶蛋白(mTOR) 免疫组织化学法 Gastric carcinom a mTOR im m uneohistochem istry
  • 相关文献

参考文献2

二级参考文献14

  • 1Lang SA, Gaumann A, Koehl GE,et al. Mammalian target of rapamycin is activated in human gastric cancer and serves as a target for therapy in an experimental model. Int J Cancer, 2007,120:1803-1810. 被引量:1
  • 2Al-Batran SE, Ducreux M, Ohtsu A. mTOR as a therapeutic target in patients with gastric cancer. Int J Cancer, 2012,130:491-496. 被引量:1
  • 3Hudes G, Cardueci M, Tomczak P, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med, 2007, 356: 2271-2281. 被引量:1
  • 4Phung TL, Ziv K, Dabydeen D, et al. Pathological angiogenesis is induced by sustained Akt signaling and inhibited by raparaycin. Cancer Cell, 2006,10 : 159-170. 被引量:1
  • 5Atkins MB, Hidalgo M, Stadler WM, et al. Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advaneed refractory renal cell carcinoma. J Clin Oneol, 2004,22,909-918. 被引量:1
  • 6Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell, 2012,149: 274-293. 被引量:1
  • 7Armengol G, Rojo F, Castellvl J, et al. 4E-binding protein 1: a key molecular " funnel factor" in human cancer with clinical implications. Cancer Res, 2007,67 : 7551-7555. 被引量:1
  • 8Fuereder T, Jaeger-Lansky A, Hoeflmayer D,et al. mTOR inhibition by everolimus counteracts VEGF induction by sunitinib and improves anti-tumor activity against gastric cancer in vivo. Cancer Lett, 2010,296:249-256. 被引量:1
  • 9Sahin F, Kannangai R, Adegbola O, et al. mTOR and P70S6 kinase expression in primary liver neoplasms. Clin Cancer Res, 2004,10:8421-8425. 被引量:1
  • 10Zhou X, Tan M, Stone Hawthorne V, et al. Activation of the Akt/mammalian target of rapamyein/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers. Clin Cancer Res, 2004,10:6779-6788. 被引量:1

共引文献19

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部