摘要
目的:分析孟鲁司特钠致儿童药物不良反应(ADR)的特点,为临床合理用药提供指导。方法:检索中国期刊全文数据库(CNKI)、万方数据库、PubMed数据库关于孟鲁司特钠致儿童ADR病例,从发生ADR患儿的性别、年龄、发生时间、转归、临床表现、累及器官-系统等方面进行分析。结果:收集到符合条件的文献15篇,共19例患儿; ADR男性患儿发生率(68.42%)明显高于女性患儿(31.58%),不良反应多发生在用药后1周内(63.16%),2～5岁儿童ADR发生率最高(36.84%);累及器官-系统以神经系统(63.16%)和消化系统(10.53%)为主,主要临床表现为睡眠障碍、注意力不集中、攻击性行为、肝功能异常等。结论:使用孟鲁司特钠时应加强监测,以减少ADR的发生。
Objective:To investigate the characteristics of pediatric adverse drug reactions(ADR)induced by montelukast,and to provide reference for rational clinical drug use.Methods:CNKI,Wanfang database and PubMed were retrieved to collect the pediatric ADR induced by montelukast,and statistical analysis was conducted on gender,age,occurrence time,prognosis,clinical manifestations and involved organs-systems.Results:Totally 15 eligible literature were collected,including 19 children.The incidence of ADR in male children was significantly higher(68.42%)than that in female children(31.58%),and most of the ADR occurred within 1 week after administration(63.16%).The incidence of ADR in children aged from 2 to 5 years was the highest(36.84%).The system-organs involved by ADR were mainly nervous system(63.16%)and digestive system(10.53%).The clinical manifestations mainly performed as sleep disorders,inattention,aggressive behavior and abnormal liver function,etc.Conclusion:Monitoring should be strengthened to reduce the incidence of ADR when montelustra sodium is used.
作者
吴光华
魏涵
闫聪聪
张淼
马姝丽
Wu Guanghua;Wei Han;Yan Congcong;Zhang Miao;Ma Shuli(Children’s Hospital Affiliated to Zhengzhou University,Henan Children’s Hospital,Zhengzhou Children’s Hospital,Henan Zhengzhou 450053,China;The First Affiliated Hospital of Zhengzhou University,Henan Zhengzhou 450052,China)
出处
《儿科药学杂志》
CAS
2019年第5期43-46,共4页
Journal of Pediatric Pharmacy
关键词
孟鲁司特钠
儿童
不良反应
montelukast sodium
children
adverse drug reactions
