摘要
目的:观察反复自然流产组(RSA)与正常早孕者血清及绒毛组织中NO含量、NOS活性和血清中VEGF含量。方法:采用比色法检测33例RSA患者及30例正常对照组血清和绒毛组织中NO含量、NOS活性,采用ELISA方法检测血清VEGF含量。结果:(1)血清中NO含量RSA组较对照组高,二者有显著差异(P<0.05);绒毛组织中NO含量RSA组较对照组高,二者有显著差异(P<0.01)。(2)血清中NOS活性RSA组较对照组高,二者有显著差异(P<0.01);绒毛组织中NOS活性RSA组较对照组高,二者有显著差异(P<0.01)。(3)血清VEGF含量RSA组较对照组高,二者有显著差异(P<0.001)。结论:RSA组血清和绒毛组织中NO含量、NOS活性及VEGF含量均较高,可能是RSA发病的原因之一。
Objective: To investigate the content of NO、 the activity of NOS in serum and chorionic villus, the content of VEGF in serum of recurrent spontaneous abortion (RSA) and control group. Methods: In 33 RSA and 30 normal pregnancy miscarry groups, NO content、 NOS activity in serum and villus were measured by colorimetry and VEGF content in serum was examined using ELISE. Results: (1 ) Content of NO in serum of RSA group was obviously higher than that of the control group (P< 0. 05) . Content of NO in chorionic villus of RSA group was obviously higher than that of the control group (P<0. 01) . (2) The NOS activity in serum of RSA group was obviously higher than that of the control group (P<0. 01). The NOS activity in chorionic villus of RSA group was obviously higher than that of the control group (P<0. 01). (3) The VEGF content in serum of RSA group was obviously higher than that of the control group (P<0. 001). Conclusion: The changes by obviously increase of content of NO、 activity of NOS in serum and chorionic villus and content of VEGF in serum of RSA group may be one of the important cause of spontaneous abortion of unknown etiology.
出处
《中国妇幼保健》
CAS
2004年第4X期20-22,共3页
Maternal and Child Health Care of China
