摘要
目的 :在用高脂饮食诱导大鼠出现肥胖、高胰岛素血症等胰岛素抵抗综合征表现的基础上 ,观察有氧运动及饮食控制对该动物模型脂质代谢的影响。方法 :选取离乳雄性SD大鼠 5 5只 ,随机分为正常对照组 13只 ,给予基础饲料 ;实验组 4 2只 ,给予高脂饮食 (含脂量 38.9% )。实验组大鼠经高脂喂养 12周后 ,随机分为 4组 ,干预 8周。H组 :继续高脂饮食 ;HL组 :低脂饮食 ;HE组 :继续高脂饮食 +游泳 ;LE组 :低脂饮食 +游泳。于实验的第 12周和2 0周 ,分别检测大鼠的胰岛素敏感性及血脂谱。结果 :12周后 ,高脂喂养鼠的Lee指数、空腹胰岛素水平及胰岛素敏感性指数明显升高。游泳干预和饮食控制组大鼠的Lee指数、甘油三酯 /高密度脂蛋白水平比值皆明显的下降 ,饮食控制组大鼠的HDL显著升高 ,而游泳干预组大鼠的TG显著降低。结论 :本实验的运动和饮食控制方案均可使大鼠的TG/HDL比值下降 。
Objective: To study the effect of exercise and diet control on the metabolic of lipoprotein of rats induced by fat rich diet. Method:55 male SD rats were randomly divided into control group (n=13) and experimental group (n=42), and given basic diet and fat rich diet respectively (fat content 38.9%). After 12 weeks, the experimental groups were randomly divided into 4 subgroups accepted intervention of 8 weeks.①Subgroup H were continually given fat rich diet; ②Subgroup HL accepted diet control only; ③Subgroup HE accepted high fat food and swimming training; ④Subgroup LE accepted diet control and swimming training. The insulin sensitivity and lipid profile of the rats were measured at the end of 12th and 20th week. Result: After being given fat rich diet 12 weeks, the levels of Lee Index, fasting insulin, IR index increased significantly in the experimental group. After 8 weeks of swimming and diet control, the Lee Index and ratio of TG/HDL reduced. The levels of HDL increased in diet control group, while the levels of TG reduced in swimming exercise. Conclusion: The experimental design of exercise and diet control can independently alleviate obesity and reduce ratio of TG/HDL. Exercise can reduce the levels of TG, while diet control can increase the levels of HDL.
出处
《中国康复医学杂志》
CAS
CSCD
2002年第5期273-276,共4页
Chinese Journal of Rehabilitation Medicine
