摘要
目的探讨冠心病与幽门螺杆菌感染、超敏C-反应蛋白的关系。方法临床选择2016年5月～2017年4月在本院就诊的不稳定型心绞痛42例,稳定型心绞痛40例,陈旧性心肌梗死40例,急性心肌梗死40例,同时选择体检健康者40例为健康对照组,应用酶联免疫吸附法检测全部研究对象的血清幽门螺杆菌抗体IgG阳性情况,应用散射速率比浊法检测全部研究对象血清中的超敏C-反应蛋白(hs-CRP)水平,比较各种类型冠心病患者和对照组的幽门螺杆菌抗体IgG阳性情况和超敏C-反应蛋白(hs-CRP)水平。结果冠心病各种疾病分期的血清超敏C-反应蛋白水平与健康对照组比较,显著增高,差异有统计学意义(P<0.05);冠心病各种疾病分期的血清超敏C-反应蛋白水平随着病情的加重而逐渐增高,即急性心肌梗死型>不稳定型心绞痛>陈旧性心肌梗死>稳定型心绞痛,差异有统计学意义(P<0.05);冠心病各种疾病分期的血清Hp-IgG抗体阳性情况与健康对照组比较,显著增高,差异有统计学意义(P<0.05);冠心病各种疾病分期的血清Hp-IgG抗体阳性情况随着病情的加重而逐渐增高,即急性心肌梗死型>不稳定型心绞痛>陈旧性心肌梗死>稳定型心绞痛,差异有统计学意义(P<0.05)。结论冠心病的病情严重程度与血清中幽门螺杆菌感染、超敏C-反应蛋白水平密切相关,可用于评估冠心病的病情严重程度。
Objective To investigate the relationship between coronary heart disease and Helicobacter pylori infection, high-sensitivity C-reactive protein. Methods 42 patients with unstable angina pectoris, 40 patients with stable angina pectoris, 40 patients with old myocardial infarction, 40 patients with acute myocardial infarction, and 40 patients with healthy physical examination were selected from May 2016 to April 2017 in the clinic. The IgG positive status of Helicobacter pylori antibody in all subjects was detected by enzyme-linked immunosorbent assay（ELISA）, and the level of high-sensitivity C-reactive protein（hs-CRP） in the serum of all subjects was detected by scattering rate turbidimetry. Helicobacter pylori antibody IgG-positive status and high-sensitivity C-reactive protein（hs-CRP） levels were compared between patients with various types of coronary heart disease and controls. Results Serum high-sensitivity C-reactive protein levels in different stages of coronary heart disease were significantly higher than those in healthy control group, and the difference was statistically significant（P〈0.05）. Serum high-sensitivity C-reactive protein levels in various stages of coronary heart disease gradually increased as the condition worsened, namely acute myocardial infarction type 〉unstable angina 〉 old myocardial infarction 〉 stable angina pectoris, and the difference was statistically significant（P〈0.05）. The serum Hp-IgG antibody positive in the stages of coronary heart disease was significantly higher than that in the healthy control group, and the difference was statistically significant（P〈0.05）. The serum Hp-IgG antibody positive status of various stages of coronary heart disease gradually increased with the severity of the disease, namely acute myocardial infarction type 〉unstable angina 〉old myocardial infarction 〉stable angina pectoris, and the difference was statistically significant（P〈0.05）. Conclusion The severity of coronary heart disease is closely related
作者
徐涛
赵燕颖
孙远杰
XU Tao;ZHAO Yanying;SUN Yuanjie(Department of Gastroenterology,Yiqi General Hospital,Changchun 130011,China)
出处
《中国现代医生》
2018年第31期37-39,共3页
China Modern Doctor
关键词
幽门螺杆菌感染
超敏C-反应蛋白
冠心病
相关性
Helicobacter pylori infection
Hypersensitive C-reactive protein
Coronary heart disease
Correlation
