摘要
目的探讨幽门螺杆菌(Hp)抗体分型检测在上消化道疾病中的临床价值分析。方法选取2019年1月—2020年2月本院收治的218例上消化道疾病患者作为研究对象,根据上消化道疾病种类进行分组,分为反流性食管炎(RE)组、慢性浅表性胃炎(CSG)组、慢性萎缩性胃炎(CAG)组、功能性消化不良(FD)组、消化性溃疡(PU)组、胃癌(GC)组。检测各组Hp感染情况和血清Hp抗体分型情况,抗体包括UreB、UreA、VacA和CagA,分型分为Ⅰ型、Ⅱ型和中间型。结果218例患者Hp感染率为73.9%,各组Hp感染率比较:PU组、GC组Hp感染率高于PD组、RE组、CSG组、CAG组,差异均有统计学意义(P<0.05)。各组Hp抗体分型分布比较:CAG组、PU组、GC组Ⅰ型占比高于FD组,差异均有统计学意义(P<0.05)。PU组、GC组UreB阳性率、UreA阳性率均较FD组、RE组、CSG组、CAG组、PU组高,差异均有统计学意义(P<0.05)。PU组VacA阳性率均高于FD组、RE组、CSG组、CAG组、PU组,差异均有统计学意义(P<0.05)。GC组CagA阳性率较FD组、RE组、CSG组高,差异均有统计学意义(P<0.05)。结论上消化道疾病普遍存在Hp感染,尤其以PU患者、GC患者Hp感染率最高,Hp抗体主要为Ⅰ型;进行Hp抗体分析利于病变程度判断,指导治疗和判断疾病预后。
Objective To analyze the value of helicobacter pylori(Hp)antibody typing in upper digestive tract diseases.Methods Between January 2019 and February 2020,218 patients be admitted to our hospital due to upper gastrointestinal diseases were enrolled as study subjects,they were divided into reflux esophagitis(RE)group,chronic superficial gastritis(CSG)group,the chronic atrophic gastritis(CAG)group,functional dyspepsia(FD)group,peptic ulcer(PU)group,and gastric carcinoma(GC)group according to disease.Detection of Hp infection situation and serum Hp antibody was performed,antibodies including UreB,UreA,VacA and CagA,and the type of the antibody including isⅠtype,Ⅱtype,and intermediate type.Results The total Hp infection rate among 218 patients was 73.85%.The Hp infection rate of PU group and GC group was higher than that of PD group,RE group,CSG group and CAG group(P<0.05).The distribution of Hp antibody among groups:the proportions of typeⅠantibody in CAG group,PU group,and GC group were higher than the FD group,differences were statistically significant(P<0.05);the positive rates of UreB and CRP in PU group and GC group were higher than FD group,RE group,CSG group,CAG group,and PU group(P<0.05);the VacA positive rate in PU group was higher than that in FD group,RE group,CSG group,CAG group and PU group(P<0.05).CagA positive rate in GC group was higher than FD group,RE group and CSG group(P<0.05).Conclusions Hp infection is common in upper gastrointestinal diseases,Hp infection rate is especially the highest in patients with PU and GC,and Hp antibody is mainly type I.Hp antibody analysis is helpful to determine the degree of lesions,guide the treatment and prognosis.
作者
吴华美
陈小曼
李建宁
WU Hua-mei(Clinical laboratory,people's hospital of Leizhou,Zhanjiang,Guangdong,524200,China.)
出处
《齐齐哈尔医学院学报》
2021年第5期391-394,共4页
Journal of Qiqihar Medical University
关键词
幽门螺杆菌
抗体分型检测
上消化道疾病
胃黏膜
Helicobacter pylori
Antibody typing detection
Diseases of the upper digestive tract
Gastric mucosa
