摘要
外泌体是由多囊泡体释放到胞外的小囊泡,可将其所携带的蛋白质、脂质、DNA、miRNA和mRNA等运输至受体细胞,并改变受体细胞的生物学行为.在多发性骨髓瘤（MM）中,外泌体可调节免疫系统、促进血管生成、癌相关成纤维细胞转化、与骨髓间充质干细胞相互作用、增强破骨细胞活性、诱导MM的耐药性等.血液中的外泌体可作为MM的早期诊断标志物,为MM患者提供一种新的诊断、治疗策略.文章就外泌体在MM中的功能与诊治研究进展作一综述.
Exosomes are small vesicles that are released from multivesicular bodies to the extracellular. They can carry proteins, lipids, DNA, miRNA and mRNA to the recipient cells, thereby altering the biological behavior of the recipient cells. In multiple myeloma （MM）, exosomes could regulate the immune system, promote angiogenesis and the transformation of cancer-associated fibroblasts, interact with bone mesenchymal stem cells, enhance osteoclast activity, and induce MM resistance. Exosomes in the blood can be used as an early diagnostic marker for MM in order to provide a new diagnosis and treatment strategy for MM patients. This article summarizes the progress of the function, diagnosis and treatment of exosomes in MM.
作者
张煜
鞠少卿
丛辉
Zhang Yu;Ju Shaoqing;Cong Hui(Laboratory Medicine Center,Affiliated Hospital of Nantong University,Nantong 226001,China)
出处
《肿瘤研究与临床》
CAS
2018年第10期717-720,共4页
Cancer Research and Clinic
基金
江苏省十三五科教强卫工程医学重点实验室“实验诊断学”（ZDXKB2016011）
江苏省卫生计划生育委员会课题（H201526）
江苏省“六大人才高峰”培养对象（WS-066）
南通市社会发展项目（MS12017008-1、HS2014059）
关键词
外泌体
多发性骨髓瘤
骨髓微环境
骨髓间充质干细胞
耐药
Exosomes
Multiple myeloma
Bone marrow microenvironment
Bone mesenchymal stem cells
Drug resistance
