摘要
目的比较非肌层浸润性膀胱癌经尿道膀胱肿瘤切除术(transurethral resection of bladder tumor,TURBT)术后吡柔比星与丝裂霉素灌注化疗的临床效果。方法选取2013年1月至2016年1月本院收治的94例非肌层浸润性膀胱癌患者为研究对象。按照随机数表法将其分为观察组和对照组,每组各47例。两组患者均接受TURBT治疗,术后对照组患者采用丝裂霉素灌注化疗,观察组患者采用吡柔比星灌注化疗,疗程均为12个月。比较两组患者不良反应发生率、生活质量各领域评分及随访24个月复发率。结果观察组患者不良反应发生率显著低于对照组(P <0.05)。治疗后两组患者社会、认知、日常生活、情感及生理评分均显著高于本组治疗前(P_均<0.05);治疗后观察组患者社会、认知、日常生活、情感及生理评分均显著高于同期对照组(P_均<0.05)。随访24个月,观察组患者复发率显著低于对照组(χ2=4.209,P <0.05)。结论非肌层浸润性膀胱癌患者TURBT术后采用吡柔比星灌注化疗,临床效果明显,不良反应少,复发率低,且可明显改善患者生活质量。
Objective To compare the clinical effects of Mitomycin and Piroxubicin infusion chemotherapy in the treatment of non-muscle invasive bladder cancer after txansurethral resection of bladder tumor （TURBT）. Method A total of 94 patients with non-muscular invasive bladder cancer admitted to our hospital from January 2013 to January 2016 were selected as research subjects. According to random number table method, they were divided into observation group and control group, 47 cases in each group. Both groups were treated by TURBT for 12 months. Patients in control group were treated by Mitomycin infusion chemotherapy after operation, while those in observation group were treated by Pirarubicin infusion chemotherapy. The incidence of adverse reactions, quality of life and the recurrence rate of 24 months after treatment were compared between the two groups. Result The incidence of adverse reactions in observation group was significantly lower than that in control group （P 〈 0.05）. After treatment, the social, cognitive, daily life, emotional and physiological scores of the two groups were significantly higher than those before treatment （Pall 〈 0.05）; after treatment, the social, cognitive, daily life, emotional and physiological scores of observation group were significantly higher than those of control group （Pall 〈 0.05）. After 24 months follow-up, the recurrence rate of observation group was significantly lower than that of control group （χ^2 = 4.209, P 〈 0.05）. Conclusion Pirarubicin infusion chemotherapy after TURBT for patients with non-muscule invasive bladder cancer has great clinical effects, less adverse reactions, lower recurrence rate, and can significantly improve the quality of life of patients.
作者
尼加提
董焱鑫
高晓康
NI Jia-ti;DONG Yan-xin;GAO Xiao-kang(Department of Urology,General Hospital of Xinjiang Command,Urumchi 830000,China)
出处
《中国医学前沿杂志（电子版）》
2018年第11期94-97,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
