摘要
目的探讨经尿道绿激光切除联合双侧髂内动脉栓塞治疗应用于中晚期膀胱癌(BC)的治疗效果。方法选取本院于2013年1月至2016年3月间收治的70例中晚期BC患者,根据不同的治疗方法将其分为观察组和对照组,观察组术前行双侧髂内动脉栓塞化疗,对照组行单纯手术治疗,两组术后均规范行膀胱灌注化疗。比较两组患者围手术期的一般情况、近期疗效及血清肿瘤标志物细胞间黏附分子-1(sICAM-1)、分泌型蛋白(DKK)、血管内皮生长因子(VEGF)及成纤维生长因子(FGF)的表达情况。结果观察组手术时间及住院时间均明显低于对照组,组间比较差异有统计学意义(P<0.05)。治疗前两组患者的血清肿瘤指标比较,差异无明显统计学意义(P>0.05),经过治疗后,血清sICAM-1、DKK、VEGF、FGF水平均明显下降,且观察组的下降幅度更明显(P<0.05)。观察组的有效率为74.28%(26/35),对照组为48.57%(17/35),组间比较差异有统计学意义(P<0.05)。结论经尿道绿激光切除联合双侧髂内动脉栓塞治疗中晚期BC的治疗效果好,能够显著减缓肿瘤生长,提高疗效。
Objective To analyze the therapeutic effect of bilateral internal iliac artery embolism combined with radical transurethral green laser vaporization in the treatment ofadvanced bladder cancer.Methods Seventy patients with advanced bladder cancer admitted to our hospital from January 2013 to March 2016 were enrolled in the study,according to different treatment methods divided them into observation group and the control group.The observation group underwent bilateral internal iliac artery embolization chemotherapy.The control group underwent surgery alone,and both groups underwent standard intravesical chemotherapy.The general conditions,short-term efficacy and serum tumor markers sICAM-1,DKK,VEGF and FGF were compared between the two groups.Results The operation time and hospitalization time of the observation group were significantly lower than those of the control group.The difference between the two groups was statistically significant(P<0.05).There was no significant difference in serum tumor index between the two groups before treatment(P>0.05).After treatment,the serum levels of sICAM-1,DKK,VEGF and FGF decreased significantly,and the decrease of the observation group was more obvious.The difference between the groups was statistically significant(P<0.05).The effective rate of the observation group was 74.28%(26/35),and that of the control group was 48.57%(17/35).The difference between the groups was statistically significant(P<0.05).Conclusions Bilateral internal iliac artery embolism combined with radical transurethral green laser vaporization is effective in treating advanced bladder cancer,which can significantly slow tumor growth and improve efficacy.
作者
高飞
张鹤
许平
卜小斌
雷普
王贵荣
Gao Fei;Zhang He;Xu Ping;Bu Xiaobin;Lei Pu;Wang Guirong(Department of Urology,the Second Hospital of Yulin City,Yulin 719000,China;Department of Urology,Gongli Hospital of Pudong New Area,Shanghai 200135,China)
出处
《国际泌尿系统杂志》
2020年第4期597-600,共4页
International Journal of Urology and Nephrology
关键词
膀胱肿瘤
栓塞
治疗性
膀胱切除术
激光
固体
Urinary Bladder Neoplasms
Embolization,Therapeutic
Cystectomy
Lasers,Solid-State
