摘要
生物被膜是细菌在生长过程中附着在生物或非生物表面的具有一定结构的微生物群体。超过65%的人类疾病与生物被膜有关,尤其是慢性疾病,主要由于细菌形成生物被膜后,会增强对抗生素和宿主免疫应答的抵抗力。生物被膜的清除对于疾病的预防和治疗具有重要意义,目前亟需开发能拮抗生物被膜的新型抗菌药物。本文就近年来生物被膜拮抗剂开发的研究进展作简要的综述。
Bacterial biofilms are a complex and organized community of bacteria encased in a self-produced exopoly-meric matrix that anchors to a live or inert surface, Over 65% of human diseases involve biofilms, and this is particularly true of chronic diseases. The formation of a biofilm can increase a bacterium＇s resistance to antibiotics and the host immune response. Removal of biofilm is a potential strategy to prevent and treat diseases involving such films. Therefore, new antibacterials need to be developed to combat biofilms. This review provides a detailed summary of recent advances in antibiofilm agents.
作者
阴银燕
何凯明
吴梦星
周悦
史艺
秦涛
YIN Yin-yan;HE Kai-ming;WU Meng-xing;ZHOU Yue;SHI Yi;QIN Tao(Department of Pathogen Biology and Immunology,Medical College of Yan gzhou University,Yangzhou 225001,Jiangsu,China;College of Veterinary Medicine,Yangzhou University,J iangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Diseases and Zoonoses)
出处
《中国病原生物学杂志》
CSCD
北大核心
2018年第10期1162-1165,共4页
Journal of Pathogen Biology
基金
国家自然科学基金项目(No.31600113)
江苏省自然科学基金项目(No.BK20160462)
江苏省高校自然科学研究面上项目(No.16KJB310020)
江苏高校优势学科建设工程项目(PAPD)
关键词
生物被膜
细菌
疾病
抑制
综述
Biofilms
bacteria
diseases
inhibition
review
