摘要
细菌生物被膜是指粘附在细胞或有机物质表面并被自身产生的胞外基质包裹所形成的聚合微生物群落,可以抵抗抗菌药物和宿主免疫系统的杀伤,是导致慢性感染的重要原因。本文对细菌生物被膜的形成与抗生物被膜感染药物研究进展进行综述,以期为临床的抗感染治疗提供参考。
Bacterial biofilm refers to the polymeric microbial community that forms by adhering to the surface of cells or organic substances and that is encased in a self-produced extracellular matrix. This biofilm can resist the killing action of antimicrobial agents and the host immune system, and it is a key cause of chronic infection. The current review provides a detailed summary of the formation of bacterial biofilm and advances in research on anti-infective agents that inhibit biofilm formation in order to provide a reference for the clinical treatment of infections.
作者
孟千琳
凌保东
MENG Qian-lin;LING Bao-dong(Key Laboratory of Sichuan Province College for Structural Specific Small Molecule Drug Research,Chengdu 610500,Sichuan,China;School of Pharmacy,Chengdu Medical College)
出处
《中国病原生物学杂志》
CSCD
北大核心
2021年第8期984-987,F0004,共5页
Journal of Pathogen Biology
基金
国家自然科学基金面上项目(No.81373454)。
