摘要
目的探究降钙素原检测方式用于慢阻肺患者抗生素治疗中的临床效果。方法以2017年1月—2018年1月医院接诊的66例慢阻肺急性加重患者为研究目标,按就诊次序标定为观察组与对照组,对照组按照抗生素治疗规定进行常规治疗,观察组则根据降钙素原测定结果为患者制定针对性的抗生素治疗方案。比对两组患者的住院指标、治疗效果及抗生素使用情况。结果观察组成员使用抗生素的概率72.73%,二重感染的概率为9.09%,对照组患者使用抗生素的概率90.91%,二重感染的概率为26.67%。观察组患者的使用抗生素的概率、二重感染概率均低于对照组,差异有统计学意义(χ~2=10.976,P=0.001);观察组患者抗生素使用时间为(6.01±1.27)d、住院时间为(8.31±1.16)d、住院费用为(5 542.19±209.43)元,均低于对照组,差异有统计学意义(t=7.673、8.667、12.488,P=0.000);观察组患者临床治疗有效率78.79%、死亡率为3.03%和有创机械通气率为12.12%,对照组患者临床治疗有效率81.82%、死亡率为3.03%和有创机械通气率为9.09%,两组数据对比,差异无统计学意义(χ~2=0.287、0.000、0.479,P=0.721、1.000、0.645)。结论对慢性阻塞性肺疾病抗生素的治疗中,在对慢阻肺患者实施抗生素治疗时,通过降钙素原检测,能够有效控制感染概率及抗生素使用概率,同时其经济适用性较好,故而具有极高的应用价值。
Objective To investigate the clinical effect of procalcitonin detection in antibiotic therapy for patients with chronic obstructive pulmonary disease. Methods Sixty-six patients with acute exacerbation of chronic obstructive pulmonary disease admitted to the hospital from January 2017 to January 2018 were selected as the observation group and the control group according to the order of treatment. The control group was routinely treated according to the antibiotic treatment regulations. A targeted antibiotic treatment regimen was developed for the patient in the observation group based on the procalcitonin assay. Compare the hospitalization index, treatment effect and antibiotic use of the two groups of patients. Results The probability of using antibiotics in the observation group was 72.73%, the probability of double infection was 9.09%, the probability of using antibiotics in the control group was 90.91%, and the probability of double infection was 26.67%. The probability of using antibiotics and the probability of double infection in the observation group were lower than those in the control group. The difference was statistically significant （χ2=10.976, P=0.001）. The antibiotic use time of the observation group was （6.01±1.27）d, hospitalization time （8.31±1.16）d and hospitalization expenses were （5 542.19±209.43） yuan, which were lower than the control group. The difference was statistically significant （t=7.673、8.667、12.488, P=0.000）. The clinical treatment of the observation group was was 78.79%, the mortality rate was 3.03%, and the invasive mechanical ventilation rate was 12.12%. The clinical treatment efficiency of the control group was 81.82%, the mortality rate was 3.03%, and the invasive mechanical ventilation rate was 9.09%, with statistical significance（χ2=0.287、0.000、0.479, P=0.721、1.000、0.645）. Conclusion In the treatment of antibiotics for chronic obstructive pulmonary disease, procalcitonin detection can effectively control the probability of infection an
作者
田安国
TIAN An-guo(Department of Respiratory,First People＇s Hospital of Zhenjiang,Zhenjiang,Jiangsu Province,212132 China)
出处
《系统医学》
2018年第19期52-54,共3页
Systems Medicine
关键词
慢性阻塞性肺疾病
抗生素
降钙素原检测
应用
Chronic obstructive pulmonary disease
Antibiotics
Procalcitonin detection
Application
