摘要
Objective： To observe the clinical therapeutic effects of acupuncture on chemotherapy-induced hand-foot syndrome（HFS）.Methods： A total of 60 patients treated with chemotherapy of capecitabine and suffering from the chemotherapy-induced HFS were divided into an acupuncture group and a Vitamin B6 group according to the random number table, 30 cases in each one. In the acupuncture group, after chemotherapy,acupuncture was given at Bǎihui（百会 GV 20）, Hégǔ（合谷 LI 4）, Wàiguān（外关 TE 5）, Zúsānlǐ（足三里ST 36） and Ashi points. The needles were retained for 30 min in each treatment, once a day, totally for 2 weeks. In the Vitamin B6 group, after chemotherapy, Vitamin B6 was taken orally, 300 mg a day, totally for 2 weeks. Separately, on the day of enrollment and after 2 weeks of treatment, the scores of Karnofsky performance scale（KPS） and the quality of life（QLQ-C30） were evaluated in the acupuncture group and the Vitamin B6 group. After 2 weeks of treatment, the therapeutic effects were evaluated.Results： The effective rate of chemotherapy-induced HFS was 70.0% in the acupuncture group and was36.7% in the Vitamin B6 group. The result in the acupuncture group was higher than the Vitamin B6 group, indicating the significant difference（P0.05）. After treatment, the KPS scores（84.23 ± 10.49） in the acupuncture group were higher obviously than the Vitamin B6 group（77.84 ± 10.33）, indicating the significant difference（P0.05）. Regarding QLQ-C30 evaluation, after 2-week treatment, the scores in the items of physical function, role function, emotional function, cognitive function and social function were all reduced remarkably as compared with those before treatment in the two groups, indicating the significant differences（all P〈0.05）. After treatment, the scores of physical function（7.13 ± 1.56 vs 16.72 ± 4.29）,emotional function（4.89 ± 0.87 vs 11.76 ± 1.29） and cognitive function（6.32 ± 1.23 vs 18.17 ± 4.1） in the acupuncture group we
目的:观察针灸治疗化疗后手足综合征的临床疗效。方法:将60例化疗后出现手足综合征的直肠癌患者按随机数表法随机分为针刺组和维生素B6组,每组30例。针刺组予针灸百会、合谷、外关、足三里、阿是穴治疗,留针30 min, 1次/日,共治疗2周;维生素B6组给予口服维生素B6,300mg/天,共治疗2周。针刺组和维生素B6组均在入组时及治疗2周后进行卡氏评分和生活质量(QLQ-C30)评价,并进行疗效评价。结果:针刺组有效率为70.0%、维生素B6组为36.7%,针刺组高于VB6组,差异有统计学意义(P<0.05)。卡氏评分:治疗后针刺组卡氏评分(84.23±10.49)明显高于维生素B6组(77.84±10.33),差异具有统计学意义(P<0.05)。QLQ-C30评分:治疗2周后两组在躯体功能、角色功能、情绪功能、认知功能和社会功能方面的评分均较治疗前明显下降,差异均有统计学意义(均P<0.05);治疗后针刺组在躯体功能(7.13±1.56vs16.72±4.29)、情绪功能(4.89±0.87vs11.76±1.29)和认知功能(6.32±1.23vs18.17±4.1)三个方面的生活治疗评分明显低于VB6组,差异均具有统计学意义(均P<0.05),而在角色功能和社会功能的评分与VB6组比较无明显差异(P>0.05)。结论:针灸可有效治疗卡培他滨化疗后手足综合征,并且在改善患者的躯体功能、情绪功能和认知功能方面疗效优于口服维生素B6。
