摘要
回顾性分析山西医科大学附属人民医院内分泌科2016年11月至2017年9月诊治的272例甲状腺相关抗体阴性2型糖尿病患者的临床资料。其中，血清25羟．维生素D[25（OH）DI〈25nmoFL者119例（严重缺乏组），≥25-〈50nmol／L者124例（缺乏组），≥50nmoUL者29例（正常及不足组）。3组间rr4总量（P=0．04）、TSH（P〈0．01）、甲状旁腺素（P=-0．03）差异均有统计学意义；经校正性别、年龄、BMI、糖尿病病程及糖化血红蛋白（HbAlc）后，血25（OH）D水平与TSH仍呈负相关（F=-0．24，P〈0．05）；在校正性别、年龄、BMI、糖尿病病程及血25（OH）D后，HbAlc与游离rr3（r=-0．18，P〈0．01）、TSH（F=-0．20，P〈0．01）呈负相关。多元线性回归分析显示TSH与血25（OH）D（B=-0．224，P〈0．01）、HbAlc（B=-0．206，P〈0．01）有线性回归关系。提示2型糖尿病患者血清维生素D、HbAlc与甲状腺功能弱相关，并独立于性别、年龄、BMI、糖尿病病程。
Two hundred and seventy two type 2 diabetes mellitus （T2DM） patients with negative anti-thyroid autoantibody were enrolled in Shanxi Provincial People＇s Hospital from November 2016 to September 2017. According to serum vitamin D levels, patients were classified as serious deficiency of vitamin D group（[25（OH）D]〈25 nmol/L, n=119）, vitamin D deficiency group （≥25 - 〈50 nmol/L, n= 124）and normal vitamin D group （≥50 nmol/L, n=29 ）. There were significant differences in total T4（P=0.04）, TSH （P〈0.01）, parathyroid hormone （P=0.03） among these groups （P〈0.05）. After adjusting gender, age, BMI, glycosylated hemoglobin （HbAlc） and duration of diabetes, serum 25（OH）D level was negatively correlated with TSH （r=-0.24, P〈0.05）. After adjusting gender, age, BMI, duration of diabetes and serum 25（OH）D level, HbAlc level was negatively correlated with free T3 （r=-0.18, P〈0.01） and TSH （r=-0.20, P〈0.01）. Multiple linear regression analysis revealed that TSH was correlated with 25（OH） D （8=-0.224, P〈0.01） and HbAlc （8=-0.206, P〈0.01）. In conclusion, the serum vitamin D and HbAlc levels are independently correlated with thyroid function in patients with T2DM.
作者
郭丽艳
郑蓉蓉
彭丹丹
赵志军
胡玲
Guo Liyan;Zheng Rongrong;Peng Dandan;Zhao Zhijun;Hu Ling(Department of Endocrinology,Shanxi Provincial People＇s Hospital Affiliated to Shanxi Medical University,Taiyuan 030012,China)
出处
《中华全科医师杂志》
2018年第10期808-810,共3页
Chinese Journal of General Practitioners
关键词
糖尿病
2型
维生素D
血红蛋白A
糖化
甲状腺功能
Diabetes mellitus
type 2
Vitamin D
Hemoglobin A
glycosylated
Thyroidfunction
