摘要
目的:了解3 340例住院患儿血清25-羟维生素D[25-(OH)D]的基线水平和儿科常见疾病谱、不同年龄段、不同性别及季节的25-(OH)D水平,并分析其与临床指标之间的相关性。方法:随机选取3 340例住院患儿,ELISA方法检测血清25-(OH)D的水平,并用Pearson相关分析探讨25-(OH)D水平与患儿临床指标如肝功能、心肌酶谱、免疫球蛋白、T淋巴细胞亚型、甲状腺功能的相关性。结果:3 340例患儿中男1 850例,女1 490例,平均血清25-(OH)D水平为(33.00±13.42)ng.m^(-1)。新生儿疾病患儿血清25-(OH)D水平最低,其次是原发性肾病综合征、过敏性紫癜及幼年类风湿性关节炎患儿。足月儿较早产儿血清25-(OH)D水平高。除新生儿外,随年龄增加,患儿血清25-(OH)D水平逐渐降低,不足百分比逐渐增加。不同年龄组男性、女性25-(OH)D水平无显著差异。住院患儿夏季25-(OH)D水平最高。25-(OH)D与体质指数(BMI)、ALT、AST、磷酸肌酸激酶(CK)、磷酸肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、游离T_4(FT_4)、游离T_3(FT_3)呈正相关,与AKP、免疫球蛋白E(Ig E)、免疫球蛋白M(Ig M)呈负相关。结论:住院患儿维生素D不足发生率较高,不同疾病其不足程度不同,血清25-(OH)D水平与BMI、过敏、心肌受损、甲状腺功能可能有一定的相关性。
Objective： To investigate the baseline levels of 25-hydroxy-vitamin D [ 25-（OH） D ] in 3340 hospitalized children, analyze the 25-（OH） D levels in children with different diseases, age and gender in different seasons, and study the correlation between the 25-（OH） D levels and the clinical indicators. Methods： Totally 3340 hospitalized children were randomly selected, the 25-（OH） D levels were detected by an ELISA method, and Pearson correlation analysis of 25-（OH） D levels and clinical indicators such as liver function, myocardial enzymes, immunoglobulins, lymphocyte subtypes and thyroid function was performed. Results： The serum 25- （OH） D level in 3340 cases （1850 male, 1490 female） was （33.00 ± 13.42） ng m1-1, and that in those with neonatal diseases was the lowest followed by those with primary nephrotic syndrome, Henoch-schordeinpurpura and juvenile idiopathic arthritis. The ser- um 25-（OH） D levels in the premature was higher than that in full term infant. Except the newborn, the level of serum 25-（OH） D gradually reduced along with the age increase, while the percentage of insufficiency gradually increased. The serum 25-（OH） D level between the male and the female had no significant difference. The 25-（OH） D levels of hospitalized children were the highest in sum- mer. The serum level of 25-（OH） D was positively correlated with body mass index （BMI）, alanine transaminase （ALT）, aspartate transaminase （ AST）, Creatine kinase （ CK）, creatine-phosphokinase （ CK-MB）, lactate dehydrogenase （ LDH）, free T4 （Fr4） and free T3 （FF3）, and negative correlation with alkaline phosphatase（ ALP）, immunoglobulin E （IgE） and immunoglobulin M （IgM）. Conclusion： The incidence of vitamin D insufficiency is high in hospitalized children. The level of vitamin D is different among various diseases. The level of serum 25-（OH） D may have certain relevance with BMI, allergies, myocardial damage and thyroid function.
出处
《中国药师》
CAS
2017年第1期99-102,共4页
China Pharmacist
基金
国家自然科学基金项目(编号:81373179)
关键词
维生素D
肝功能
心肌酶
住院
儿童
Vitamin D
Liver function
Myocardial enzyme
Hospitalized
Children
