摘要
肝细胞因子(hepatokines)是指仅由肝脏或主要由肝脏分泌入血直接影响糖脂代谢的蛋白,这些肝细胞因子在糖尿病肾病(diabetic nephropathy,DN)发生、发展过程中起着重要作用,尤其在胰岛素抵抗的病理生理机制中起到加速或延缓的作用。正确认识它们对我们早期诊断及治疗DN具有重要的指导意义。本文就近年来国内外关于肝细胞因子在DN中发病机制的研究进展进行归纳总结。
Hepatokines is a protein excreted into the blood only or mainly by the liver that directly affects glycolipid metabolism. It can accelerate and delay the occurrence and development of diabetic nephropathy, especially in the pathophysiological mechanism of insulin resistance.It directly affects lipid metabolism. Our understanding towards them is of great significance for the early diagnosis and treatment of diabetic nephropathy. In this paper, recent advances on the pathogenesis of hepatokines in diabetic nephropathy are summarized.
作者
高燕
李林倩
王倩
张思
张海松
Gao Yan;Li Linqian;Wang Qian;Zhang Si;Zhang Haisong(Department of Nephrology,the Affiliated Hospital of Hebei Medical University,Baoding 071000,China;Hebei University,Baoding 071000,China)
出处
《临床荟萃》
CAS
2018年第10期859-862,共4页
Clinical Focus
基金
河北省重点研发计划健康医疗与生物医药专项项目(18277722D)
