摘要
目的:比较不同性别毒性弥漫性甲状腺肿病(Graves病,GD)患者的临床特征及伴发甲状腺功能亢进(简称甲亢)性心脏病的危险因素。方法:回顾性分析2009年1月至2017年1月,727例GD患者的临床资料,按性别进行分组,对其临床特征及合并甲亢性心脏病的危险因素进行对比分析。结果:与男性组比较,女性组表现为GD发病年龄更低(χ~2=3.038,P=0.007),弥漫性甲状腺肿发生率更高(χ~2=13.480,P=0.000),甲亢性心脏病发生率更低(χ~2=4.023,P=0.045),血FT4和TRAb水平更高(t=63367.0,P=0.009;t=63895.5,P=0.016)。多因素Logistics回归分析结果显示,男性GD患者合并甲亢性心脏病的危险因素包括病程(OR=1.882,95%CI:1.250~5.024,P=0.006)和合并弥漫性甲状腺肿(OR=3.011,95%CI:1.746~10.348,P=0.000),女性GD患者合并甲亢性心脏病的危险因素包括发病年龄(OR=1.302,95%CI:1.009~2.195,P=0.011)、病程(OR=2.026,95%CI:1.318~4.207,P=0.000)和血FT4水平(OR=2.129,95%CI:1.615~6.713,P=0.000)。结论:不同性别GD患者临床特征和发生甲亢性心脏病的危险因素可能存在差异。
Objective： To compare the clinical characteristics and risk factor of hyperthyroid cardiopathy between different gender patients with Graves disease（ GD） Methods： 727 GD patients from January 2009 to January 2017 were recruited to participate in the study. According to the gender,they were divided into two groups. To compare the clinicopathological features and risk factor of hyperthyroid cardiopathy between two groups. Results： Compared with male group,more patients of female group were found with younger onset age（ t = 3. 038,P = 0. 007）,higher rate of diffuse goiter（ χ~2= 13. 480,P = 0. 000）,lower rate of hyperthyroid cardiopathy（ χ~2= 4. 023,P = 0. 045） and higher level of serum FT4 and TRAb（ t = 63367. 0,P = 0. 009; t =63895. 5,P = 0. 016） Multiariable logistic regression analysis showed that durmion of disease（ OR = 1. 882,95% CI： 1. 250-5. 024,P = 0. 006） and diffuse goiter（ OR = 3. 011,95% CI： 1. 746-10. 348,P = 0. 000） were associated with hyperthyroid cardiopathy for male GD patients. Meanwhile,the onset age（ OR = 1. 302,95%CI： 1. 009-2. 195,P = 0. 011）,durmion of disease（ OR = 2. 026,95% CI： 1. 318-4. 207,P = 0. 000） and serum level of FT4（ OR = 2. 129,95% CI： 1. 615-6. 713,P = 0. 000） were associated with hyperthyroid cardiopathy for female GD patients. Conclusion： There may be significant differences in clinical characteristics and risk factors of hyperthyroid cardiopathy of between different gender GD patients.
作者
姬文娜
魏改丽
JI Wenna;WEI Gaili(Department of Endocrinology,Yan＇an People＇s Hospital,Yanan 716000,China)
出处
《心肺血管病杂志》
2018年第9期823-826,共4页
Journal of Cardiovascular and Pulmonary Diseases
关键词
GRAVES病
甲亢性心脏病
不同性别
危险因素
临床特征
Graves disease
Hyperthyroid cardiopathy
Gender identity
Risk factor
Clinical characteristics
