摘要
近几年,国内外展开了高通量测序(high-throughput sequencing,HTS)对T细胞受体库的研究,T细胞作为机体适应性免疫应答的执行者,其表面的T细胞受体(T-cell receptor,TCR)是适应性免疫应答的关键。目前,国内以同卵双胞胎(monozygotic twins,MZ)为研究背景对TCR受体库的研究并不多。为了能够更好地了解相同遗传背景下,健康个体以及免疫相关疾病患者TCR受体库特征,该文将结合健康同卵双胞胎TCR受体库特征以及患有免疫系统相关疾病的同卵双胞胎TCR受体库特征进行简要综述。
In recent years, high-throughput sequencing has been applied to study T cell receptor（TCR） in domestic and foreign. As the executor of the adaptive immune response, the T cell receptor（TCR） on the surface of T cell is the key to the adaptive immune response. At present, there are not enough studies about TCR on the background of monozygotic twins. In order to better understand the characteristic of TCR receptor repertoire of healthy individual and patient suffering from immune-related disease under the same genetic background, this article will summarize the characteristic of TCR receptor repertoire of healthy monozygotic twins and the characteristic of TCR receptor repertoire of monozygotic twins suffering from immune-related disease.
作者
苏丹华
董晓衡
马龙
姚新生
Su Danhua;Dong Xiaoheng;Ma Long;Yao Xinsheng(Special Key Laboratory of Gene Detection ＆ Therapy of Guizhou Province,Department of Immunology,Zunyi Medical University,Zunyi 563000,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2018年第9期1606-1611,共6页
Chinese Journal of Cell Biology
基金
贵州省科学技术基金项目(批准号:黔科合LH字[2014]7568号)资助的课题~~
