摘要
目的探讨全程营养管理对肿瘤患者化疗前后营养变化的影响，为规范肿瘤患者的临床营养支持提供依据。方法选择2016年1月至2017年12月拟行第一次化疗的患者88例，将患者按病种不同随机分为两组：干预组和对照组，各44例。两组的抗肿瘤治疗手段相同，同时均予以常规营养支持（根据患者开始化疗入院时的营养筛査及营养评估情况，制定个体化营养支持方案，予以具体的膳食指导），干预组在常规营养支持基础上，营养师定期随访患者的病情变化、胃肠道反应、进食状况等，遵循营养不良的五阶梯治疗模式，及时完善营养干预方案，提供适宜的营养支持。化疗结束后，分别比较两组患者化疗前后体质量、白蛋白、前白蛋白、血红蛋白的变化。结果化疗结束后两组患者的白蛋白、前白蛋白、血红蛋白较化疗前均无明显下降（P〉0.05）。干预组患者化疗后体质量平稳，未见明显下降（P〉0.05），对照组化疗后较化疗前体质量下降明显[（54.61 ± 10.76）kg比（56.52 ± 10.46）kg]，差异有统计学意义（P〈0.05）。结论全程营养管理可以预防肿瘤患者化疗期间血白蛋白、血前白蛋白、血红蛋白下降，尤其是体质量下降。
ObjectiveTo investigate the effect of full nutrition management on cancer patients with chemotherapy, and to support theory bases for the standardized clinical nutrition of cancer patients.MethodsFrom January 2016 to December 2017, a total of 88 patients with the first chemotherapy were recruited and randomly divided into experimental group and control group, with 44 patients in each group. These patients all complied with the inclusion and exclusion criteria, and volunteered for the study. The two groups all received the same of anti-tumor treatment and the same conventional nutritional support （according to the results of nutrition screening and nutrition assessment, the nutritional support was formulated and patients′ dietary guidance was given）, while only patients of the experimental group were given full nutritional management, including regularly following up the patient′s condition changes, gastrointestinal reactions, and the feed. According to the five-step treatment model of malnutrition, nutritional support was improved in a timely manner, and appropriate nutritional support was provided. At the end of chemotherapy, the change of weight, albumin, prealbumin, hemoglobin was compared with that before treatment in the two groups.ResultsAfter chemotherapy, albumin, prealbumin, hemoglobin had no obvious drop compared with that before treatment in two groups （P〉0.05）. The patients of experimental group showed stable weight after chemotherapy： （53.39 ± 9.24） kg vs. （54.66 ± 9.41） kg, P〉0.05. Weight loss in the control group after chemotherapy was statistically significant： （54.61 ± 10.76） kg vs. （56.52 ± 10.46） kg, P〈0.05.ConclusionsThe full nutritional management can help maintain nutrition status during chemotherapy, especially can prevent the weight loss.
作者
李缨
钱红娟
黄芸
宣琪
任晓艺
吴琼
相前
Li Ying;Qian Hongjuan;Huang Yun;Xuan Qi;Ren Xiaoyi;Wu Qiong;Xiang Qian(Department of Nutrition,Xuanwu Hospital,Capital Medical University,Beijing100053,China)
出处
《中国医师进修杂志》
2018年第10期901-904,共4页
Chinese Journal of Postgraduates of Medicine
关键词
营养管理
化疗
营养状况
Nutritional management
Chemotherapy
Nutrition status
