摘要
目的:探讨晚期非小细胞肺癌患者的营养状况及营养支持对患者的临床疗效和营养指标的影响。方法:选取我院收治的晚期非小细胞肺癌住院患者60例,随机分为营养支持组和对照组,均采用TP方案进行化疗。在化疗前应用NRS-2002量表进行营养风险评估,在化疗过程中对营养支持组的患者进行饮食指导和营养支持;而对照组则不给予任何营养指导和支持。比较2组患者的近期疗效、毒副反应和化疗前、后营养指标的变化。结果:晚期非小细胞肺癌住院患者营养风险的发生率为61.7%。和对照组比较,营养支持组患者的化疗有效率无显著差异,但化疗后的骨髓抑制发生率显著低于对照组,差异有统计学意义(P<0.05)。治疗前,营养支持组和对照组患者的体质量指数(BMI)、白蛋白(ALB)、血红蛋白(Hb)和前白蛋白(PA)等营养指标均无显著差异。治疗后,营养支持组患者的BMI、ALB、Hb和PA等营养指标均有所改善,但对照组患者仅有ALB有所改善;并且,治疗后营养支持组患者的各项营养指标均优于对照组,差异有统计学意义(P<0.05)。结论:晚期非小细胞肺癌患者的营养风险发生率高。营养支持可明显地改善晚期非小细胞癌患者的营养状况,减轻其化疗毒副反应,提高化疗耐受性。
Objective： To investigate the nutritional status of patients with advanced non-small cell lung cancer（ NSCLC） and the effect of nutritional support on the efficiency and toxicity of chemotherapy and nutrient indicators.Methods： Totally 60 patients with advanced NSCLC were randomly divided into nutritional support group and control group with TP chemotherapy. NRS-2002 was used to perform nutritional risk screening before chemotherapy. The nutritional support group were given the nutritional support during chemotherapy,while the control group was given clinical routine treatments. Compared the efficiency and toxicity of chemotherapy and the changes of nutrient indicators.Results： The incidence of nutritional risk of hospitalized patients with advanced NSCLC was 61. 7%. Compared with the control group,the effective rate of chemotherapy of the nutritional support group had no significant difference. The incidence of bone marrow suppression was significantly lower in the nutritional support group than that of the control group. There was no significant difference of nutrient indicators such as BMI,ALB,Hb and PA between two groups before chemotherapy. The nutrient indicators of BMI,ALB,Hb and PA in the nutritional support group were improved after chemotherapy,while only ALB was improved in the control group. The nutrient indicators of the nutritional support group were significantly better than the control group after treatment. Conclusion： Patients with advanced NSCLC have a high incidence of nutrition risk. Nutritional support can improve the nutritional status of patients with advanced NSCLC and reduce the toxicity of chemotherapy.
出处
《现代肿瘤医学》
CAS
2015年第22期3246-3250,共5页
Journal of Modern Oncology
基金
湛江市2014年科技攻关项目(编号:2014B10157)
关键词
非小细胞肺癌
营养状况
营养支持
化疗
non-small cell lung cancer
nutritional status
nutritional support
chemotherapy
