摘要
目的探讨小金丸联合戈舍瑞林治疗子宫内膜异位症的临床疗效。方法选取2017年2月—2017年9月在海南省人民医院治疗的子宫内膜异位症患者82例,根据用药差别分为对照组(41例)和治疗组(41例)。对照组患者于月经结束后第2天开始腹前壁皮下注射醋酸戈舍瑞林缓释植入剂,3.6 mg/次,1次/28 d;治疗组在对照组基础上口服小金丸,3 g/次,2次/d。两组均经过6个月治疗。观察两组患者临床疗效,同时比较治疗前后两组患者性激素水平、血清学指标、子宫内膜厚度、Kupperman和VAS评分及肿瘤标志物水平。结果治疗后,对照组和治疗组的总有效率分别为80.49%、95.12%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组促卵泡成熟激素(FSH)、黄体生成素(LH)、雌二醇(E2)、中性粒细胞激活肽-78(ENA-78)、基质金属蛋白酶-9(MMP-9)、血管内皮生长因子(VEGF)、抗子宫内膜抗体(EMAb)、糖抗原125(CA125)和糖抗原199(CA199)水平均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗后治疗组这些指标水平明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组子宫内膜厚度显著缩小(P<0.05),Kupperman和VAS评分明显降低(P<0.05),且治疗组子宫内膜厚度、Kupperman和VAS评分明显优于对照组(P<0.05)。结论小金丸联合戈舍瑞林治疗子宫内膜异位症可有效改善患者临床症状,改善机体性激素水平,降低机体肿瘤标记物水平,具有一定的临床推广应用价值。
Objective To observe the curative effect of Xiaojin Pills combined with goserelin in treatment of endometriosis. Methods Patients（82 cases） with endometriosis in Hainan General Hospital from February 2017 to September 2017 were divided into control（41 cases） and treatment（41 cases） groups based on different treatments. Patients in the control group were anterior abdominal subcutaneous injection administered with Goserelin Acetate Sustained-Release Depot from the 2 nd day after end of menstruation, 3.6 mg/time, once every 28 d. Patients in the treatment group were po administered with Xiaojin Pills on the basis of the control group, 3 g/time, twice daily. Patients in two groups were treated for 6 months. After treatment, the clinical efficacy was evaluated, and the sex hormone levels, the serological indexes, the endometrial thickness, Kupperman and VAS scores, the tumor markers levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 80.49% and 95.12% respectively, and there were differences between two groups（P 〈 0.05）. After treatment, the FSH, LH, E2, ENA-78, MMP-9, VEGF, EMAb, CA125, and CA199 levels in two groups were significantly decreased, and the difference was statistically significant in the same group（P 〈 0.05）, and these indexes levels in the treatment group after treatment were significantly lower than those in the control group, with significant difference between two groups（P 〈 0.05）. After treatment, the endometrial thickness in two groups was significantly reduced（P 〈 0.05）, Kupperman and VAS scores were significantly decreased（P 〈 0.05）, and the endometrial thickness, and Kupperman and VAS scores in the treatment group after treatment were significantly better than those in the control group（P 〈 0.05）. Conclusion Xiaojin Pills combined with goserelin in treatment of endometriosis can effectively improve the clinical symptoms and the hormone level, reduce t
作者
杨扬
龚护民
袁少洋
YANG Yang;GONG Hu-min;YUAN Shao-yang(Department of Obstetrics and Gynecology,Hainan General Hospital,Haikou 570311,China)
出处
《现代药物与临床》
CAS
2018年第9期2326-2330,共5页
Drugs & Clinic
