摘要
目的探讨血必净注射液联合常规治疗对脓毒症患者生存质量及调节性T细胞(Treg)蛋白表达的影响。方法选取海南省人民医院2013年10月~2016年10月住院治疗脓毒症患者120例,按照随机数字表分为对照组和治疗组。其中对照组58例,予常规治疗;治疗组62例,采用常规治疗联合静脉注射血必净注射液。观察两组患者治疗后的生存质量及治疗前后血清Treg水平变化及Treg蛋白表达情况。结果治疗后对照组患者生存质量12例提高,25例稳定,21例下降;治疗组患者生存质量45例提高,15例稳定,2例下降。两组患者生存质量比较,差异有统计学意义(P<0.05)。两组患者治疗前血清Treg水平及其蛋白表达量比较,差异无统计学意义(P>0.05);而治疗后两组血清Treg水平及其蛋白表达量较本组治疗前显著下降,治疗组患者血清Treg水平及其蛋白表达量均低于对照组,差异有统计学意义(P<0.05)。对照组患者生存率显著低于治疗组,差异有统计学意义(P<0.05)。结论血必净联合常规治疗能有效提高脓毒症患者的生存质量,抑制血清Treg蛋白表达可能是其作用机制之一,进而调节免疫功能发挥作用。
Objective To investigate the effect of Xuebijing Injection combined with conventional treatment on the quality of life and the protein expression of regulatory T cell （Treg） in sepsis patients. Methods A total of 120 patients with sepsis admitted to Hainan General Hospital ft＇om October 2013 to October 2016 were selected and divided into control group and treatment group according to random number table method, 58 cases in the control group were treated with conventional treatment, 62 cases in the treatment group were treated with conventional treatment combined with Xuebijing Injection intravenous injection. The quality of life, the level of serum Treg and the expression of Treg protein between the two groups Mler treatment were observed. Results After treatment, 12 cases＇ quality of life improved, 25 cases were stable and 21 cases declined in the control group; 45 cases＇ quality of life improved, 15 cases were stable and 2 cases declined in the treatment group; the difference between the two groups was statistically significant （P 〈 0.05）. Before treatment, the level of serum Treg and the expression protein of Treg between the two groups had no sig- nificant difference （P 〉 0.05）. After treatment, the level of serum Treg and the expression protein of Treg in the two groups were lower than those before treatment, and the indices in the treatment group were significant lower than those in the control group, the differences were statistically significant （P 〈 0.05）. The survival rate of the control group was remarkably lower than that of the treatment group, and the difference was significant （P 〈 0.05）. Conclusion Xuebijing Injection combined with conventional treatment can effectively improve the quality of life of patients with sepsis, and inhibit the expression of serum Treg protein, that may be one of its action mechanisms, so as to regulate the immune function.
作者
陈明科
朱永
李娜
谢晓红
CHEN Mingke;ZHU Yong;LI Na;XIE Xiaohong(Intensive Care Unit,Hainan General Hospital,Hainan Province,Haikou 570311,China)
出处
《中国医药导报》
CAS
2018年第26期100-102,124,共4页
China Medical Herald
基金
海南省自然科学基金项目(814322)
