摘要
目的制备氯雷他定纳米混悬剂,并对其稳定性进行考察。方法采用反溶剂沉淀法制备氯雷他定纳米混悬剂,利用粒度测定仪和透射电镜对纳米混悬剂形态进行表征,筛选最优处方,采用高效液相色谱法考察其稳定性。结果最优处方稳定剂为十二烷基硫酸钠,有机相为乙醇,药载比1∶2,有机相水相比5∶10,高剪切5 min制得氯雷他定纳米混悬剂呈淡蓝色,纳米粒呈类球形,平均粒径112.8 nm,多分散指数为0.095,Zeta电位为-38.6 m V;混悬剂于室温避光条件下物理与化学稳定性最佳。结论氯雷他定纳米混悬剂制备方法简便可行,稳定性良好,有望成为氯雷他定新型纳米给药系统。
Objective To prepare loratadine nanoparticle suspension and investigate the stability of it.Methods Loratadine nanoparticle suspension was prepared by anti-tumor agent precipitation method,the nanosuspension was characterized by particle size analyzer and transmission electron microscopy,the optimal prescription was screened,and the stability of nanosuspension was investigated by HPLC.Results The optimal prescription stablizer was SDS and organic phase was ethanol.The drug loading radio was 1 ： 2 and the proportion of organic phase to water was 5 ： 10 and the time of high shear was 5 min.Loratadine suspension was pale blue with a uniform emulsion.The nanoparticles were spherical,with an average particle size of 112.8 nm,the PDI of 0.095 and the Zeta potential of -38.6 mV.The suspension had the best physical and chemical stability at room temperature.Conclusion The preparation method of loratadine suspension with good stability is simple,and it’s expected to become the new nano-drug delivery system of loratadine.
作者
石淼
张洪
吕舰
白瑞丹
黄萃园
SHI Miao;ZHANG Hong;LYU Jian;BAI Ruidan;HUANG Cuiyuan(Department of Pharmacy,the People＇s Hospital of Wuhan University,Wuhan 430060,China)
出处
《医药导报》
CAS
北大核心
2018年第11期1381-1385,共5页
Herald of Medicine
关键词
氯雷他定
纳米混悬剂
稳定性
Loratadine；Nanoparticle suspension；Stability
