摘要
目的制备不含稳定剂且稳定存在的辅酶Q10(coenzyme Q10,CoQ10)纳米裸晶。方法分别以沉降法和逆向沉降法制备纳米裸晶,并运用激光粒度仪、zeta电位仪和透射电镜(transmission electron microscope,TEM)考察制剂的理化性质。结果确定最终处方工艺,得到粒径范围在80~700 nm内的纳米裸晶,其中粒径为(82.6±5.4)、(118.2±14.5)、(388.6±19.8)和(675.1±53.4)nm制剂的zeta电位分别为-(34.20±0.47)、-(29.23±0.34)、-(17.68±0.37)和-(6.54±1.78)mV,透射电镜观察纳米裸晶呈圆球状。结论成功制备了不含稳定剂的CoQ10纳米裸晶。
Objective To prepare stable CoQ10 naked nanocrystal without any surfactant or polymer. Methods CoQ10 naked nanocrystals were prepared by precipitation method and anti-precipitation method. The laser light scattering technique, zeta potential analyzer and TEM were employed to study the physicochemical properties of naked nanocrystal. Results Naked nanocrystals with different sizes ranging from 80 nm to 700 nm were prepared. The zeta potential of nanocrystals with the size of(82.6 ± 5.4)、(118.2 ± 14.5)、(388.6 ± 19.8) and(675.1 ± 53.4) nm were-(34.20 ± 0.47)、-(29.23 ± 0.34)、-(17.68 ± 0.37) and-(6.54 ± 1.78) mV, respectively. TEM images show that nanocrystals were spherical. Conclusions Through optimizing the formulations and preparation conditions, CoQ10 naked nanocrystals were successfully prepared without stabilizer.
出处
《中国药剂学杂志（网络版）》
2014年第3期73-80,共8页
Chinese Journal of Pharmaceutics：Online Edition
关键词
药剂学
纳米裸晶
沉降法
逆向沉降法
CoQ10
粒径
pharmaceutics
naked nanocrystal
precipitation method
anti-precipitation method
coenzyme Q10
size
