摘要
目的探讨利伐沙班预防老年股骨粗隆间骨折术后深静脉血栓(DVT)形成的效果。方法选取2015年11月~2017年4月我院收治的80例老年股骨粗隆间骨折患者作为研究对象,按照随机数字表法分为两组,每组各40例。利伐沙班组行利伐沙班片治疗,低分子肝素钙组行低分子肝素钙注射液治疗。观察两组术前、术后1 h、术后12 h的凝血指标[血小板(PLT)、谷丙转氨酶(ALT)、活化部分凝血活酶时间(APTT)]以及术中出血量、术后引流量、术后DVT发生率。结果两组患者术后1、12 h的PLT、APTT水平均低于术前,ALT水平高于术前,差异有统计学意义(P<0.05);两组患者术后1、12 h的PLT、APTT、ALT水平比较,差异无统计学意义(P>0.05);两组患者的术中出血量、术后引流量比较,差异无统计学意义(P>0.05)。所有患者经6个月随访,利伐沙班组患者的DVT发生率为2.5%,低于低分子肝素钙组的15.0%,差异有统计学意义(P<0.05)。结论老年股骨粗隆间骨折行利伐沙班治疗对患者凝血功能影响小,可显著降低术后DVT发生率。
Objective To explore the effect of ttivaroxaban in prevention of post-operative deep venous thrombosis （DVT） afler intertroehanterie fracture of femur in elderly patients. Methods Altogether 80 elderly patients with in- tertroehanterie fractures of femur who were treated in our hospital from November 2015 to April 2017 were selected as the subjects, and divided into two groups according to the random number table method, with 40 cases in each group. The ttivaroxaban group was treated with ttivaroxaban Tablets, while the low molecular weight heparin calcium （LMWHC） group were administered with injection of LMWHC. The coagulation indexes before operation and at post- operative 1 and 12 hours, including platelet （PLT）, alanine aminotransferase （ALT） and activated partial thromboplastin time （APTT）, as well as intra-operative hemorrhage, post-operative drainage and post-operative deep vein thrombosis （DVT） incidence of two groups were observed. Results The PLT and APTT levels of the two groups at post-operative 1 and 12 hours were lower than those before operation, and the ALT levels of the two groups was higher than that be- fore operation, with statistically significant difference （P〈0.05）. There were no statistically significant differences in the levels of PLT, APTF and ALT between the two groups at post-operative 1 and 12 hours （P〉0.05）. There were no statis- tically significant differences in intra-operative hemorrhage and drainage volume between the two groups （P〉0.05）. All the patients were followed up for 6 months. The incidence of DVT of ttivaroxaban group was 2.5%, lower than that of LMWHC group, with statistically significant difference （P〈0.05）. Conclusion Application of Rivaroxaban in the treat- ment of elderly patients with intertroehanterie fracture of femur has little effect on coagulation function, and can signifi- cantly reduce the incidence of post-operative DVT.
作者
颜建华
谢青
YAN Jian-hua;XIE Qing(Ji＇an Hospital of Traditional Chinese Medicine in Jiangxi Province,Ji＇an 343000,China)
出处
《中国当代医药》
2018年第28期109-112,共4页
China Modern Medicine
关键词
利伐沙班
低分子肝素钙
股骨粗隆间骨折
深静脉血栓
临床疗效
Rivaroxaban
Low molecular weight heparin calcium
Intertroehanterie fracture of femur
Deep venous thrombosis
Clinical efficacy
