摘要
目的比较股骨转子间骨折围术期应用利伐沙班和低分子肝素(LMWH)对失血风险和深静脉血栓形成(deep venous thrombosis,DVT)的预防作用。方法选取2010年10月—2013年9月收治的67例股骨转子间骨折患者,根据术后抗凝策略分为利伐沙班组31例和LMWH组36例,利伐沙班组于术前和术后首日晨予利伐沙班口服;LMWH组于术前和术后首日予LMWH皮下注射。比较两组围术期失血情况及DVT发生率。结果两组显性失血量、出血事件发生率、DVT发生率比较差异均无统计学意义(P>0.05),LMWH组隐性失血量大于利伐沙班组(P<0.05)。结论利伐沙班与LMWH抗凝效果相当,但利伐沙班能减少术后隐性失血。
Objective To compare the effects of Rivaroxaban and low-molecular weight heparin（ LMWH） in prevention of blood loss risk and deep venous thrombosis（ DVT） for perioperative patients with femoral intertrochanteric fracture. Methods A total of 67 inpatients with femoral intertrochanteric fractures during October 2010 and September2013 were divided into Rivaroxaban group（ n = 31） and LMWH group（ n = 36） according to postoperative anticoagulants. Rivaroxaban group underwent oral Rivaroxaban medication at the first morning before and after operation,while the LMWH group underwent subcutaneous injection of LMWH at the first morning before and after operation. The incidence rate of perioperative blood loss was compared,and the DVT incidence rate was also compared in the two groups. Results The differences in values of dominant blood loss volume,the incidence rates of bleeding events and DVT were not statistically significant in the two groups（ P 0. 05）. The volume of hidden blood loss in LMWH group was larger than that in Rivaroxaban group（ P 0. 05）. Conclusion Rivaroxaban and LMWH have similar anticoagulation,but Rivaroxaban can decrease the incidence rates of hidden blood loss.
出处
《解放军医药杂志》
CAS
2015年第10期91-93,99,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
河北省医学科学研究重点课题(ZD20140317)
关键词
利伐沙班
肝素
低分子量
髋骨折
手术后出血
静脉血栓形成
Rivaroxaban
Heparin
low-molecular-weight
Hip fractures
Postoperative hemorrhage
Venous thrombosis
